Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CTSA | P10619 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3666223 | 0.95 | GPR139 (0.44) | GPR139MMP8POLBCTSATRPM8 | |
| SCHEMBL21287988 | 0.86 | TRPM8 (0.43) | GPR139POLBTRPM8TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL28936698 | 0.85 | TRPM8 (0.42) | GPR139POLBTRPM8TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL28936699 | 0.85 | TRPM8 (0.42) | GPR139POLBTRPM8TSHRMAPK1 | |
| SCHEMBL15647495 | 0.82 | POLB (0.55) | MMP8POLBTSHRL3MBTL1 | |
| SCHEMBL1433326 | 0.82 | L3MBTL1 (0.56) | MMP8TSHRMAPK1TDP1L3MBTL1 | |
| SCHEMBL1275951 | 0.80 | CTSA (0.47) | GPR139CTSATRPM8TSHR | |
| SCHEMBL22965287 | 0.80 | POLB (0.45) | GPR139POLBCTSATRPM8 | |
| SCHEMBL30836057 | 0.79 | CES2 (0.49) | MMP8POLB | |
| SCHEMBL1043810 | 0.79 | CES2 (0.49) | MMP8POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9314025-B2 | Mixtures of mesoionic pesticides | E I DU PONT DE NEMOURS AND COMPANY (US) | 2016-04-19 | — | — | US | disclosed |
| US-9018220-B2 | Mesoionic pesticides | E I DU PONT DE NEMOURS AND COMPANY (US) | 2015-04-28 | — | — | US | disclosed |
| US-20140187776-A1 | MIXTURES OF MESOIONIC PESTICIDES | E I DU PONT DE NEMOURS AND COMPANY (US) | 2014-07-03 | — | — | US | disclosed |
| US-8697707-B2 | Mixtures of mesoionic pesticides | E I DU PONT DE NEMOURS AND COMPANY (US) | 2014-04-15 | — | — | US | disclosed |
| US-20130338002-A1 | MESOIONIC PESTICIDES | E I DU PONT DE NEMOURS AND COMPANY (US) | 2013-12-19 | — | — | US | disclosed |
| US-8552007-B2 | Mesoionic pesticides | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2013-10-08 | — | — | US | disclosed |
| EP-2240454-B1 | MESOIONIC PESTICIDES | DU PONT (US) | 2013-04-24 | — | — | EP | disclosed |
| EP-2559687-A1 | Mesoionic pesticides | E. I. du Pont de Nemours and Company (US) | 2013-02-20 | — | — | EP | disclosed |
| EP-2461685-A2 | MIXTURES OF MESOIONIC PESTICIDES | E. I. du Pont de Nemours and Company (US) | 2012-06-13 | — | — | EP | disclosed |
| US-20120115722-A1 | MIXTURES OF MESOIONIC PESTICIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-05-10 | — | — | US | disclosed |
| WO-2011017351-A2 | MIXTURES OF MESOIONIC PESTICIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-02-10 | — | — | WO | disclosed |
| US-20100323887-A1 | MESOIONIC PESTICIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140187776-A1 | MIXTURES OF MESOIONIC PESTICIDES | DDT, C5, CBR3 | GPR139 1288/4885MMP8 4564/4885POLB 4120/4885 |
| US-20100323887-A1 | MESOIONIC PESTICIDES | DDT, CHRM1, CHRM3 | GPR139 451/4885MMP8 4298/4885POLB 4546/4885 |
| US-20120115722-A1 | MIXTURES OF MESOIONIC PESTICIDES | DDT, C5, CBR3 | GPR139 1288/4885MMP8 4564/4885POLB 4120/4885 |
| US-20130338002-A1 | MESOIONIC PESTICIDES | DDT, CHRM1, CHRM3 | GPR139 451/4885MMP8 4298/4885POLB 4546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.