SCHEMBL12759885

SCHEMBL12759885

Cc1ccc(-n2nccc2-c2ccccc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MDM2 Q00987 1/20 0.52
MAPK9 P45984 2/20 0.51
MAPK10 P53779 2/20 0.51
ALDH1A1 P00352 2/20 0.50
MAPT P10636 1/20 0.50
ATM Q13315 1/20 0.50
NR3C2 P08235 1/20 0.49
KDM5A P29375 2/20 0.47
KDM4C Q9H3R0 2/20 0.47
KDM5B Q9UGL1 2/20 0.47
KDM4A O75164 1/20 0.47
MAPK8 P45983 1/20 0.46
NPC1 O15118 2/20 0.46
RAB9A P51151 2/20 0.46
CYP2C9 P11712 4/20 0.46
CYP2C19 P33261 2/20 0.46
HTT P42858 2/20 0.45
FLT3 P36888 1/20 0.45
CYP2C18 P33260 1/20 0.44
MAPK1 P28482 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17086633 0.93 MDM2 (0.52) MDM2MAPK9MAPK10ALDH1A1MAPT
SCHEMBL17086629 0.91 MAPT (0.54) MDM2MAPK9MAPK10ALDH1A1MAPT
SCHEMBL5907310 0.87 MAPK9 (0.56) MDM2MAPK9MAPK10ALDH1A1NR3C2
SCHEMBL1155787 0.87 MDM2 (0.55) MDM2MAPK9MAPK10ALDH1A1NR3C2
SCHEMBL18433787 0.85 KDM5A (0.43) MDM2MAPK9MAPK10ALDH1A1MAPT
SCHEMBL28097403 0.83 NR3C2 (0.51) MDM2MAPK9MAPK10ALDH1A1MAPT
SCHEMBL17086616 0.83 ALDH1A1 (0.55) MAPK9MAPK10ALDH1A1MAPTATM
SCHEMBL17086632 0.83 MEN1 (0.50) MAPK9MAPK10ALDH1A1MAPTATM
SCHEMBL27742800 0.82 MAPK9 (0.51) MDM2MAPK9MAPK10ALDH1A1NR3C2
SCHEMBL19240299 0.82 POLB (0.52) MDM2MAPK9MAPK10ALDH1A1NR3C2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150311455-A1 Method Of Forming Metal Complex Compound, And Organic Electroluminescence Device UDC IRELAND LTD (IE) 2015-10-29 US disclosed
US-20150311455-A1 Method Of Forming Metal Complex Compound, And Organic Electroluminescence Device UDC IRELAND LTD (IE) 2015-10-29 US disclosed
US-9062084-B2 Method of forming metal complex compound, and organic electroluminescence device UDC Ireland (IE) 2015-06-23 US disclosed
US-9062084-B2 Method of forming metal complex compound, and organic electroluminescence device UDC Ireland (IE) 2015-06-23 US disclosed
US-20110050093-A1 METHOD OF FORMING METAL COMPLEX COMPOUND, AND ORGANIC ELECTROLUMINESCENCE DEVICE FUJIFILM CORPORATION (JP) 2011-03-03 US disclosed
US-20110050093-A1 METHOD OF FORMING METAL COMPLEX COMPOUND, AND ORGANIC ELECTROLUMINESCENCE DEVICE FUJIFILM CORPORATION (JP) 2011-03-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110050093-A1 METHOD OF FORMING METAL COMPLEX COMPOUND, AND ORGANIC ELECTROLUMINESCENCE DEVICE ZFR, PORCN, OR10J3 MDM2 2011/4885MAPK9 1941/4885MAPK10 2637/4885
US-20150311455-A1 Method Of Forming Metal Complex Compound, And Organic Electroluminescence Device ZFR, PORCN, OR10J3 MDM2 2011/4885MAPK9 1941/4885MAPK10 2637/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.