Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.52 |
| ▸ | KDM4A | O75164 | 1/20 | 0.50 |
| ▸ | KDM5A | P29375 | 1/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.50 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17086632 | 0.91 | MEN1 (0.50) | MAPTALDH1A1ATMNR3C2KDM4A | |
| SCHEMBL17086616 | 0.91 | ALDH1A1 (0.55) | MAPTALDH1A1ATMNR3C2KDM4A | |
| SCHEMBL12759885 | 0.91 | MDM2 (0.52) | MAPTALDH1A1ATMNR3C2KDM4A | |
| SCHEMBL17086633 | 0.91 | MDM2 (0.52) | MAPTALDH1A1ATMNR3C2KDM4A | |
| SCHEMBL17086615 | 0.88 | MAPT (0.52) | MAPTALDH1A1ATMNR3C2NPC1 | |
| SCHEMBL17086614 | 0.87 | MEN1 (0.48) | MAPTALDH1A1ATMNR3C2KDM4A | |
| SCHEMBL8188525 | 0.86 | ALDH1A1 (0.44) | MAPTALDH1A1ATMNR3C2KDM4A | |
| SCHEMBL17369543 | 0.86 | PTGS2 (0.64) | KDM5AKDM4CKDM5BCYP2C9PTGS2 | |
| SCHEMBL28097403 | 0.85 | NR3C2 (0.51) | MAPTALDH1A1ATMNR3C2KDM4A | |
| SCHEMBL13333580 | 0.84 | PTGS2 (0.60) | CYP2C9CYP3A4PTGS2PTGS1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9440962-B2 | Benzisoxazoles | HOFFMANN-LA ROCHE INC. (US) | 2016-09-13 | — | — | US | disclosed |
| US-20150259334-A1 | BENZISOXAZOLES | HOFFMANN-LA ROCHE INC. (US) | 2015-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150259334-A1 | BENZISOXAZOLES | CDR2, CHRNA5, CHRNA3 | MAPT 101/4885ALDH1A1 239/4885ATM 197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.