Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | BAD | Q92934 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GRK2 | P25098 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28412588 | 0.71 | PTGS2 (0.43) | BCL2L1BADAPPCYP3A4CYP2C9 | |
| SCHEMBL23878282 | 0.67 | POLB (0.41) | BCL2L1BADAPPCYP3A4CYP2C9 | |
| SCHEMBL6499224 | 0.65 | SLC6A3 (0.51) | BCL2L1BADKMT2APTGS2PTGS1 | |
| SCHEMBL28148964 | 0.65 | BCL2L1 (0.40) | BCL2L1BADAPPCYP3A4CYP2C9 | |
| SCHEMBL28026523 | 0.64 | BCL2L1 (0.39) | BCL2L1BADAPPCYP3A4CYP2C9 | |
| SCHEMBL7183318 | 0.61 | LIG1 (0.36) | APPCYP3A4CYP2C9CYP2C19HSD11B1 | |
| SCHEMBL8327797 | 0.61 | LIG1 (0.36) | APPCYP3A4CYP2C9CYP2C19HSD11B1 | |
| SCHEMBL4320799 | 0.61 | BCL2L1 (0.43) | BCL2L1BADHSD11B1KMT2APTGS2 | |
| SCHEMBL17761264 | 0.60 | APP (0.54) | APPCYP3A4CYP2C9CYP2C19HSD11B1 | |
| Bicarbonate SCHEMBL28812694 | 0.60 | BCL2L1 (0.68) | BCL2L1BADKMT2AHTTAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937264-B1 | COMBINATION THERAPY FOR THE TREATMENT OF URINARY FREQUENCY, URINARY URGENCY AND URINARY INCONTINENCE | MERCK SHARP & DOHME (US) | 2011-06-08 | — | — | EP | disclosed |
| US-7893091-B2 | Combination therapy for the treatment of urinary frequency, urinary urgency and urinary incontinence | MERCK SHARP & DOHME CORP. (US) | 2011-02-22 | — | — | US | disclosed |