Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12724691 | 0.74 | EGFR (0.33) | EGFRERBB2SRCKDR | |
| SCHEMBL13128156 | 0.72 | SMN1; SMN2 (0.42) | EGFRERBB2SRCMEN1KMT2A | |
| SCHEMBL7791483 | 0.72 | GRIN2D (0.44) | MEN1KMT2A | |
| SCHEMBL7791487 | 0.72 | GRIN2D (0.44) | MEN1KMT2A | |
| SCHEMBL15067485 | 0.71 | EGFR (0.33) | EGFRERBB2SRCKDR | |
| SCHEMBL15067487 | 0.71 | EGFR (0.33) | EGFRERBB2SRCKDR | |
| SCHEMBL7788578 | 0.70 | TRPA1 (0.40) | — | |
| SCHEMBL7788223 | 0.70 | MAOA (0.40) | PTGS2MEN1GAAKMT2A | |
| SCHEMBL7788581 | 0.70 | TRPA1 (0.40) | — | |
| SCHEMBL7788227 | 0.70 | MAOA (0.40) | PTGS2MEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932284-B2 | Indole sulfonamide modulators of progesterone receptors | ELI LILLY AND COMPANY (US) | 2011-04-26 | — | — | US | disclosed |