Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Acetylthiocholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 3/20 | 0.43 |
| ▸ | CHRM3 known ✓ | P20309 | 3/20 | 0.43 |
| ▸ | ACHE known ✓ | P22303 | 5/20 | 0.41 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 1.00 |
| ▸ | ATM | Q13315 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.95 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetylthiocholine SCHEMBL77666 | 0.97 | CYP2C19 (1.00) | BLMPOLBATMCYP2C19CHRM5 | |
| Acetylthiocholine SCHEMBL400577 | 0.95 | CYP2C19 (0.95) | BLMPOLBATMCYP2C19CHRM5 | |
| Acetylthiocholine SCHEMBL4318613 | 0.95 | CYP2C19 (0.95) | BLMPOLBATMCYP2C19CHRM5 | |
| Acetylthiocholine SCHEMBL27356791 | 0.95 | CYP2C19 (0.95) | BLMPOLBATMCYP2C19CHRM5 | |
| Acetylthiocholine SCHEMBL16322376 | 0.95 | CYP2C19 (0.95) | BLMPOLBATMCYP2C19CHRM5 | |
| Acetylthiocholine SCHEMBL7172548 | 0.95 | CYP2C19 (0.95) | BLMPOLBATMCYP2C19CHRM5 | |
| Acetylthiocholine SCHEMBL4318618 | 0.95 | CYP2C19 (0.95) | BLMPOLBATMCYP2C19CHRM5 | |
| Acetylthiocholine SCHEMBL28994784 | 0.89 | BLM (0.80) | BLMPOLBATMCYP2C19CHRM5 | |
| Acetylthiocholine SCHEMBL9097185 | 0.89 | CYP2C19 (0.83) | BLMPOLBATMCYP2C19CHRM5 | |
| Acetylthiocholine SCHEMBL28776641 | 0.87 | CYP2C19 (0.79) | BLMPOLBATMCYP2C19CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 271 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118406492-B | Preparation method and application of metal doped carbon dots | 北京师范大学 | 2026-05-15 | — | — | CN | claimed |
| US-20250283140-A1 | Deep Eutectic Solvent Stabilized Enzyme-Based Electrochemical Assay Probes for Use in the Field | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY | 2025-09-11 | — | — | US | claimed |
| CN-119492791-A | Preparation and application of multifunctional electrochemical sensor based on bionic catalyst functionalized nano-sheet | 中国科学院大连化学物理研究所 | 2025-02-21 | — | — | CN | claimed |
| CN-118956855-A | Biosensor, preparation method and application thereof | 中国石油大学(华东) | 2024-11-15 | — | — | CN | claimed |
| CN-118604078-A | Preparation method of MXene-based molybdenum disulfide platinum and application of MXene-based molybdenum disulfide platinum to electrochemical detection of organophosphorus pesticides | 江苏大学 | 2024-09-06 | — | — | CN | claimed |
| CN-118406492-A | Preparation method and application of metal doped carbon dots | 北京师范大学 | 2024-07-30 | — | — | CN | claimed |
| CN-117990755-A | Electrochemical biosensor modified by conductive covalent organic framework material and preparation method and application thereof | 中国科学院大连化学物理研究所 | 2024-05-07 | — | — | CN | claimed |
| CN-117969622-A | Biosensor of sandwich-like zinc-based composite material | 天津科技大学 | 2024-05-03 | — | — | CN | claimed |
| CN-117434125-A | Electrochemical biosensor based on copper-based conductive metal organic framework modification and preparation method and application thereof | 中国科学院大连化学物理研究所 | 2024-01-23 | — | — | CN | claimed |
| WO-2023229993-A1 | OPHTHALMIC FORMULATION CAPABLE OF DELIVERING METFORMIN TO CHOROID RPE AND RETINA | CURATIVE BIOTECHNOLOGY, INC. (US) | 2023-11-30 | — | — | WO | claimed |
| CN-114650813-A | Druggable targets for the treatment of retinal degeneration | 美国卫生和人力服务部 | 2022-06-21 | — | — | CN | claimed |
| CN-114250220-A | Preparation and application of dopamine-coated sea urchin-shaped manganese dioxide hollow microspheres | 中国科学院兰州化学物理研究所 | 2022-03-29 | — | — | CN | claimed |
| CN-112345607-B | Triazophos biosensor based on two-dimensional nano material | 苏州健雄职业技术学院 | 2021-12-03 | — | — | CN | claimed |
| CN-109959684-B | Preparation of double-identification type chlorpyrifos sensor, method for detecting chlorpyrifos residues in vegetables and detection device | 扬州工业职业技术学院 | 2021-07-13 | — | — | CN | claimed |
| WO-2021050980-A1 | DRUGGABLE TARGET TO TREAT RETINAL DEGENERATION | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES (US) | 2021-03-18 | — | — | WO | claimed |
| CN-112345607-A | Triazophos biosensor based on two-dimensional nano material | 苏州健雄职业技术学院 | 2021-02-09 | — | — | CN | claimed |
| CN-112114016-A | Electrochemical method for detecting 3-nitropropionic acid | 广西壮族自治区农业科学院农产品质量安全与检测技术研究所 | 2020-12-22 | — | — | CN | claimed |
| US-20200390852-A1 | COMPOSITIONS AND METHODS FOR TREATING PERIPHERAL NERVE DISEASE, DISORDERS, AND INJURIES | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2020-12-17 | — | — | US | claimed |
| CN-111007137-A | Method and equipment for detecting organic phosphorus | 重庆文理学院 | 2020-04-14 | — | — | CN | claimed |
| WO-2018170359-A1 | COMPOSITIONS AND METHODS FOR TREATING PERIPHERAL NERVE DISEASE, DISORDERS, AND INJURIES | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2018-09-20 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200390852-A1 | COMPOSITIONS AND METHODS FOR TREATING PERIPHERAL NERVE DISEASE, DISORDERS, AND INJURIES | GAP43, EPHA4, EPHA3 | CHRM1 244/4885CHRM3 182/4885ACHE 128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.