Sugi Predict

Sugi Predict / Compounds / SCHEMBL127709

SCHEMBL127709

SCHEMBL127709

[CH2]Cc1ccc(C(F)(F)F)cc1

nearest known ligand 0.54

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ TAAR1 Q96RJ0 1/20 0.54
▸ IDO1 P14902 4/20 0.52
▸ MAOB P27338 4/20 0.47
▸ ALDH1A1 P00352 3/20 0.45
▸ KDM4E B2RXH2 1/20 0.45
▸ KIF11 P52732 2/20 0.44
▸ KMT2A Q03164 1/20 0.44
▸ MIF P14174 1/20 0.44
▸ TSHR P16473 1/20 0.43
▸ EPHX2 P34913 1/20 0.41
▸ SRD5A2 P31213 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27900254 0.93 MAOB (0.57) TAAR1IDO1MAOBKIF11
SCHEMBL5534895 0.87 MAPK14 (0.48) TAAR1IDO1MAOBKMT2AEPHX2
SCHEMBL398644 0.80 TAAR1 (0.61) TAAR1IDO1MAOBALDH1A1KDM4E
SCHEMBL18378219 0.80 TAAR1 (0.35) TAAR1IDO1MAOBALDH1A1KDM4E
SCHEMBL3073272 0.79 TAAR1 (0.54) TAAR1IDO1MAOBALDH1A1KDM4E
SCHEMBL2096666 0.78 SRD5A2 (0.59) TAAR1IDO1MAOBALDH1A1KDM4E
SCHEMBL934227 0.78 TAAR1 (0.73) TAAR1IDO1MAOBALDH1A1KDM4E
SCHEMBL1119524 0.77 TAAR1 (0.57) TAAR1IDO1MAOBKMT2AMIF
SCHEMBL130132 0.77 NR1H2 (0.52) —
SCHEMBL18245502 0.77 TAAR1 (0.33) TAAR1IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1122 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023237580-A1 TRICYCLIC SPIROLACTAM COMPOUNDS WITH ANTIMYCOBACTERIAL ACTIVITY INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) 2023-12-14 — — WO claimed
US-20230348387-A1 NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF ALECTOS THERAPEUTICS INC. (CA) 2023-11-02 — — US claimed
US-20230278958-A1 TRICYCLIC HETEROCYCLES MERCK PATENT GMBH (DE) 2023-09-07 — — US claimed
US-20230174538-A1 Tricyclic heterocycles MERCK PATENT GMBH (DE) 2023-06-08 — — US claimed
US-20230174486-A1 NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF ALECTOS THERAPEUTICS INC. (CA) 2023-06-08 — — US claimed
EP-4185564-A1 TRICYCLIC HETEROCYCLES Merck Patent GmbH (DE) 2023-05-31 — — EP claimed
WO-2023078813-A1 HETEROBIFUNCTIONAL MOLECULES AS TEAD INHIBITORS MERCK PATENT GMBH (DE) 2023-05-11 — — WO claimed
EP-4168409-A1 VMAT2 INHIBITORS AND METHODS OF USE Neurocrine Biosciences, Inc. (US) 2023-04-26 — — EP claimed
EP-4146624-A1 NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF Alectos Therapeutics Inc. (CA) 2023-03-15 — — EP claimed
EP-4146623-A1 NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF Alectos Therapeutics Inc. (CA) 2023-03-15 — — EP claimed
US-20020065248-A1 Inhibitors of hepatitis C virus NS3 protease BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-05-30 — — US claimed
US-20010031758-A1 Substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives: selective neuropeptide Y receptor ligands NEUROGEN CORPORATION 2001-10-18 — — US claimed
US-6127381-A A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY LION BIOSCIENCE AG (DE) 2000-10-03 — — US claimed
WO-1999051598-A1 SUBSTITUTED 9H-PYRIDINO[2,3-b]INDOLE AND 9H-PYRIMIDINO[4,5-b]INDOLE DERIVATIVES: SELECTIVE NEUROPEPTIDE y RECEPTOR LIGANDS NEUROGEN CORPORATION (US) 1999-10-14 — — WO claimed
US-5416101-A FUNGICIDES ROHM AND HAAS COMPANY (US) 1995-05-16 — — US claimed
US-5389612-A Treating infections caused by clostridium histolyticum and pseudomonas aeruginosa; enzyme inhibitors COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) 1995-02-14 — — US claimed
EP-0606748-A1 Cyanosulfonylethyltriazoles and their use as fungicides ROHM AND HAAS COMPANY (US) 1994-07-20 — — EP claimed
EP-0328830-B1 4-Heteropentacyclic-4- N-(phenyl)amido piperidine compounds OHMEDA PHARMA PROD (US) 1994-06-01 — — EP claimed
US-5308860-A Fungicides ROHM AND HAAS COMPANY (US) 1994-05-03 — — US claimed
EP-0328830-A1 4-Heteropentacyclic-4- N-(phenyl)amido piperidine compounds Ohmeda Pharmaceutical Products Division Inc. (US) 1989-08-23 — — EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230348387-A1 NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF GBA1, GBA2, GAA TAAR1 4166/4885IDO1 2392/4885MAOB 1282/4885
US-20230278958-A1 TRICYCLIC HETEROCYCLES YAP1, TERF2IP, TEAD1 TAAR1 3949/4885IDO1 3982/4885MAOB 4095/4885
US-20020065248-A1 Inhibitors of hepatitis C virus NS3 protease TMPRSS15, CTRC, CPN1 TAAR1 2386/4885IDO1 1672/4885MAOB 2950/4885
US-20230174486-A1 NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF GBA1, GBA2, GAA TAAR1 4166/4885IDO1 2392/4885MAOB 1282/4885
US-20230174538-A1 Tricyclic heterocycles YAP1, TEAD1, TERF2IP TAAR1 3665/4885IDO1 3847/4885MAOB 4130/4885
US-20010031758-A1 Substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives: selective neuropeptide Y receptor ligands NPY1R, NPY2R, NPY5R TAAR1 93/4885IDO1 67/4885MAOB 168/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.