Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | DHFR | P00374 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12789251 | 0.84 | MEN1 (0.56) | MEN1KMT2APOLBALDH1A1NPC1 | |
| SCHEMBL12846922 | 0.83 | MEN1 (0.39) | MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL12788356 | 0.82 | KDM4E (0.49) | MEN1KMT2ADHFRALDH1A1 | |
| SCHEMBL12788809 | 0.82 | KMT2A (0.45) | MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL12788348 | 0.81 | PDE3B (0.41) | MEN1KMT2ADHFRALDH1A1 | |
| SCHEMBL12847203 | 0.81 | MEN1 (0.37) | MEN1KMT2APOLBNPC1 | |
| SCHEMBL12847376 | 0.80 | KMT2A (0.40) | MEN1KMT2APOLBDHFRALDH1A1 | |
| SCHEMBL5864193 | 0.78 | MEN1 (0.88) | MEN1KMT2APOLBDHFRALDH1A1 | |
| SCHEMBL12789849 | 0.77 | DHFR (0.36) | MEN1KMT2APOLBDHFRALDH1A1 | |
| SCHEMBL12788804 | 0.76 | POLB (0.39) | MEN1KMT2APOLBDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110065671-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | MERCK SHARP & DOHME CORP. | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065671-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | GPR119, GPR39, GPR65 | MEN1 3069/4885KMT2A 3444/4885POLB 4577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.