Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BHMT | Q93088 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | EYA2 | O00167 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1280078 | 0.90 | BHMT (0.39) | BHMTMAPTALDH1A1ALDH2CHRM2 | |
| SCHEMBL1280281 | 0.83 | BHMT (0.47) | BHMTALDH1A1ALDH2CHRM2TDP1 | |
| SCHEMBL1280629 | 0.76 | HSD17B10 (0.53) | BHMTMAPTALDH1A1TDP1ALOX15 | |
| SCHEMBL1280200 | 0.76 | BHMT (0.44) | BHMTTDP1EYA2APPACE | |
| SCHEMBL16608921 | 0.75 | HSD17B10 (0.56) | MAPTALDH1A1TDP1APPALOX15 | |
| SCHEMBL890300 | 0.75 | MAPT (0.50) | BHMTMAPTALDH1A1ALDH2CHRM2 | |
| SCHEMBL6207947 | 0.74 | MAPT (0.38) | BHMTMAPTALDH1A1ALDH2CHRM2 | |
| SCHEMBL22766987 | 0.71 | TDP1 (0.54) | BHMTALDH1A1CHRM2TDP1EYA2 | |
| SCHEMBL29319565 | 0.69 | TDP1 (0.52) | BHMTCHRM2TDP1EYA2APP | |
| SCHEMBL18401328 | 0.69 | TDP1 (0.56) | BHMTALDH1A1CHRM2TDP1EYA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10065992-B2 | Cyclosporin analogs | ALLERGAN, INC. (US) | 2018-09-04 | — | — | US | claimed |
| EP-2627664-B1 | CYCLOSPORIN ANALOGS | ALLERGAN INC (US) | 2018-04-04 | — | — | EP | claimed |
| EP-2855508-B1 | CYCLOSPORIN A ANALOGS | ALLERGAN INC (US) | 2018-02-14 | — | — | EP | claimed |
| US-20170029469-A1 | CYCLOSPORIN ANALOGS | ALLERGAN, INC. | 2017-02-02 | — | — | US | claimed |
| US-9493511-B2 | Cyclosporin analogs | ALLERGAN, INC. (US) | 2016-11-15 | — | — | US | claimed |
| US-9266927-B2 | Cyclosporin A analogs | ALLERGAN, INC. (US) | 2016-02-23 | — | — | US | claimed |
| US-20160039880-A1 | CYCLOSPORIN A ANALOGS | ALLERGAN, INC. | 2016-02-11 | — | — | US | claimed |
| EP-2855508-A2 | CYCLOSPORIN A ANALOGS | ALLERGAN, INC. (US) | 2015-04-08 | — | — | EP | claimed |
| US-20150065433-A1 | CYCLOSPORIN ANALOGS | ALLERGAN, INC. (US) | 2015-03-05 | — | — | US | claimed |
| WO-2013181339-A2 | CYCLOSPORIN A ANALOGS | ALLERGAN, INC. (US) | 2013-12-05 | — | — | WO | claimed |
| US-20130324480-A1 | CYCLOSPORIN A ANALOGS | ALLERGAN, INC. | 2013-12-05 | — | — | US | claimed |
| EP-2627664-A1 | CYCLOSPORIN ANALOGS | Allergan, Inc. (US) | 2013-08-21 | — | — | EP | claimed |
| WO-2012051194-A1 | CYCLOSPORIN ANALOGS | ALLERGAN, INC. (US) | 2012-04-19 | — | — | WO | claimed |
| US-20120088734-A1 | Cyclosporin Analogs | ALLERGAN, INC. (US) | 2012-04-12 | — | — | US | claimed |
| US-10065992-B2 | Cyclosporin analogs | ALLERGAN, INC. (US) | 2018-09-04 | — | — | US | disclosed |
| EP-2627664-B1 | CYCLOSPORIN ANALOGS | ALLERGAN INC (US) | 2018-04-04 | — | — | EP | disclosed |
| EP-2855508-B1 | CYCLOSPORIN A ANALOGS | ALLERGAN INC (US) | 2018-02-14 | — | — | EP | disclosed |
| EP-2627664-A1 | CYCLOSPORIN ANALOGS | Allergan, Inc. (US) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012051194-A1 | CYCLOSPORIN ANALOGS | ALLERGAN, INC. (US) | 2012-04-19 | — | — | WO | disclosed |
| US-20120088734-A1 | Cyclosporin Analogs | ALLERGAN, INC. (US) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039880-A1 | CYCLOSPORIN A ANALOGS | TSLP, CHP1, PPP3R1 | BHMT 3124/4885MAPT 3620/4885ALDH1A1 3905/4885 |
| US-20150065433-A1 | CYCLOSPORIN ANALOGS | CHP1, TSLP, PPP3R1 | BHMT 3906/4885MAPT 3665/4885ALDH1A1 4113/4885 |
| US-10065992-B2 | Cyclosporin analogs | CHP1, TSLP, PPP3R1 | BHMT 3906/4885MAPT 3665/4885ALDH1A1 4113/4885 |
| US-20120088734-A1 | Cyclosporin Analogs | CHP1, TSLP, PPP3R1 | BHMT 3906/4885MAPT 3665/4885ALDH1A1 4113/4885 |
| US-20170029469-A1 | CYCLOSPORIN ANALOGS | CHP1, TSLP, PPP3R1 | BHMT 3906/4885MAPT 3665/4885ALDH1A1 4113/4885 |
| US-20130324480-A1 | CYCLOSPORIN A ANALOGS | TSLP, CHP1, PPP3R1 | BHMT 3124/4885MAPT 3620/4885ALDH1A1 3905/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.