Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BHMT | Q93088 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | MVD | P53602 | 1/20 | 0.31 |
| ▸ | EYA2 | O00167 | 1/20 | 0.30 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
| ▸ | ACE | P12821 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1280281 | 0.80 | BHMT (0.47) | BHMTTDP1HIF1AMVDEYA2 | |
| SCHEMBL1280629 | 0.77 | HSD17B10 (0.53) | BHMTTDP1KMT2AHSD17B10 | |
| SCHEMBL1279809 | 0.76 | BHMT (0.44) | BHMTTDP1HIF1AMVDEYA2 | |
| SCHEMBL16608921 | 0.76 | HSD17B10 (0.56) | TDP1APPKMT2AHSD17B10 | |
| SCHEMBL1280642 | 0.74 | BHMT (0.37) | BHMTTDP1HIF1A | |
| SCHEMBL1280078 | 0.73 | BHMT (0.39) | BHMTTDP1MVDEYA2APP | |
| SCHEMBL1280303 | 0.73 | BHMT (0.39) | BHMTHIF1A | |
| SCHEMBL1280251 | 0.72 | — | — | |
| SCHEMBL2560448 | 0.72 | — | — | |
| SCHEMBL11214853 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10065992-B2 | Cyclosporin analogs | ALLERGAN, INC. (US) | 2018-09-04 | — | — | US | claimed |
| EP-2627664-B1 | CYCLOSPORIN ANALOGS | ALLERGAN INC (US) | 2018-04-04 | — | — | EP | claimed |
| US-20170029469-A1 | CYCLOSPORIN ANALOGS | ALLERGAN, INC. | 2017-02-02 | — | — | US | claimed |
| US-9493511-B2 | Cyclosporin analogs | ALLERGAN, INC. (US) | 2016-11-15 | — | — | US | claimed |
| US-20150065433-A1 | CYCLOSPORIN ANALOGS | ALLERGAN, INC. (US) | 2015-03-05 | — | — | US | claimed |
| EP-2627664-A1 | CYCLOSPORIN ANALOGS | Allergan, Inc. (US) | 2013-08-21 | — | — | EP | claimed |
| WO-2012051194-A1 | CYCLOSPORIN ANALOGS | ALLERGAN, INC. (US) | 2012-04-19 | — | — | WO | claimed |
| US-20120088734-A1 | Cyclosporin Analogs | ALLERGAN, INC. (US) | 2012-04-12 | — | — | US | claimed |
| US-10065992-B2 | Cyclosporin analogs | ALLERGAN, INC. (US) | 2018-09-04 | — | — | US | disclosed |
| EP-2627664-B1 | CYCLOSPORIN ANALOGS | ALLERGAN INC (US) | 2018-04-04 | — | — | EP | disclosed |
| US-20170029469-A1 | CYCLOSPORIN ANALOGS | ALLERGAN, INC. | 2017-02-02 | — | — | US | disclosed |
| US-9493511-B2 | Cyclosporin analogs | ALLERGAN, INC. (US) | 2016-11-15 | — | — | US | disclosed |
| US-20150065433-A1 | CYCLOSPORIN ANALOGS | ALLERGAN, INC. (US) | 2015-03-05 | — | — | US | disclosed |
| EP-2627664-A1 | CYCLOSPORIN ANALOGS | Allergan, Inc. (US) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012051194-A1 | CYCLOSPORIN ANALOGS | ALLERGAN, INC. (US) | 2012-04-19 | — | — | WO | disclosed |
| US-20120088734-A1 | Cyclosporin Analogs | ALLERGAN, INC. (US) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150065433-A1 | CYCLOSPORIN ANALOGS | CHP1, TSLP, PPP3R1 | BHMT 3906/4885TDP1 2386/4885HIF1A 3937/4885 |
| US-10065992-B2 | Cyclosporin analogs | CHP1, TSLP, PPP3R1 | BHMT 3906/4885TDP1 2386/4885HIF1A 3937/4885 |
| US-20120088734-A1 | Cyclosporin Analogs | CHP1, TSLP, PPP3R1 | BHMT 3906/4885TDP1 2386/4885HIF1A 3937/4885 |
| US-20170029469-A1 | CYCLOSPORIN ANALOGS | CHP1, TSLP, PPP3R1 | BHMT 3906/4885TDP1 2386/4885HIF1A 3937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.