Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.50 |
| ▸ | CNR2 | P34972 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13185665 | 0.88 | REN (0.51) | RENCNR2LMNAALDH1A1POLB | |
| SCHEMBL3631071 | 0.86 | POLB (0.60) | RENCNR2LMNAALDH1A1POLB | |
| SCHEMBL195224 | 0.86 | LMNA (0.58) | RENCNR2LMNAALDH1A1MEN1 | |
| SCHEMBL1667374 | 0.82 | OPRK1 (0.41) | CNR2LMNACHRM2HTR1AADRA2A | |
| SCHEMBL3456186 | 0.81 | LMNA (0.68) | RENCNR2LMNAALDH1A1MEN1 | |
| SCHEMBL11574138 | 0.80 | ALOX5 (0.65) | ALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL31296669 | 0.79 | LMNA (0.51) | RENCNR2LMNAALDH1A1POLB | |
| SCHEMBL19405101 | 0.79 | TDP1 (0.69) | RENCNR2POLBAPEX1TDP1 | |
| SCHEMBL20347999 | 0.78 | ALOX5 (0.54) | RENCNR2LMNAALDH1A1TRPM8 | |
| SCHEMBL1667193 | 0.78 | CYP1A2 (0.55) | LMNAALDH1A1MEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |