Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 5/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6361527 | 0.86 | LMNA (0.50) | LMNAGAATDP1ATMBRD4 | |
| SCHEMBL11539400 | 0.83 | LMNA (0.48) | LMNAGAATDP1ATMBRD4 | |
| SCHEMBL108862 | 0.81 | LMNA (0.56) | LMNAGAATDP1ALDH1A1USP2 | |
| SCHEMBL24724656 | 0.81 | GAA (0.49) | LMNAGAATDP1ATMBRD4 | |
| SCHEMBL11536851 | 0.81 | ALDH1A1 (0.49) | LMNAGAATDP1ATMBRD4 | |
| SCHEMBL11535313 | 0.80 | ALDH1A1 (0.48) | LMNAGAATDP1ATMBRD4 | |
| SCHEMBL5780754 | 0.80 | GAA (0.48) | LMNAGAATDP1ATMBRD4 | |
| SCHEMBL11536831 | 0.80 | POLB (0.58) | LMNAGAATDP1ATMBRD4 | |
| SCHEMBL11276698 | 0.79 | LMNA (0.57) | LMNAGAATDP1ALDH1A1USP2 | |
| SCHEMBL12292649 | 0.79 | LMNA (0.57) | LMNAGAATDP1ALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |