SCHEMBL12806533

SCHEMBL12806533

CC(=O)COCCOCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCCCC(=O)O)C(=O)O

nearest known ligand 0.67

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ GLP1R P43220 8/20 0.67
▸ NOD1 Q9Y239 4/20 0.46
▸ CCKAR P32238 3/20 0.43
▸ CCKBR P32239 3/20 0.43
▸ FOLH1 Q04609 3/20 0.41
▸ GLO1 Q04760 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18697474 1.00 GLP1R (0.67) GLP1RNOD1CCKARCCKBRFOLH1
SCHEMBL13293965 1.00 GLP1R (0.67) GLP1RNOD1CCKARCCKBRFOLH1
SCHEMBL16182631 1.00 GLP1R (0.67) GLP1RNOD1CCKARCCKBRFOLH1
SCHEMBL24284196 1.00 GLP1R (0.67) GLP1RNOD1CCKARCCKBRFOLH1
SCHEMBL12287742 1.00 GLP1R (0.67) GLP1RNOD1CCKARCCKBRFOLH1
SCHEMBL24198476 1.00 GLP1R (0.67) GLP1RNOD1CCKARCCKBRFOLH1
SCHEMBL23051891 1.00 GLP1R (0.67) GLP1RNOD1CCKARCCKBRFOLH1
SCHEMBL24899310 1.00 GLP1R (0.67) GLP1RNOD1CCKARCCKBRFOLH1
SCHEMBL20911267 1.00 GLP1R (0.67) GLP1RNOD1CCKARCCKBRFOLH1
SCHEMBL19243816 1.00 GLP1R (0.67) GLP1RNOD1CCKARCCKBRFOLH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3189071-B1 NOVEL AMYLIN AND CALCITONIN RECEPTOR AGONIST NOVO NORDISK AS (DK) 2021-07-28 — — EP disclosed
US-20190112348-A1 PROTEASE STABILIZED, ACYLATED INSULIN ANALOGUES NOVO NORDISK AS (DK) 2019-04-18 — — US disclosed
US-10259856-B2 Protease stabilized acylated insulin analogues NOVO NORDISK A/S (DK) 2019-04-16 — — US disclosed
US-10174082-B2 Amylin and calcitonin receptor agonist NOVO NORDISK A/S (DK) 2019-01-08 — — US disclosed
US-9688737-B2 Protease stabilized acylated insulin analogues NOVO NORDISK A/S (DK) 2017-06-27 — — US disclosed
US-20170145059-A1 Novel Amylin And Calcitonin Receptor Agonist NOVO NORDISK AS (DK) 2017-05-25 — — US disclosed
US-9593149-B2 Amylin and calcitonin receptor agonist NOVO NORDISK A/S (DK) 2017-03-14 — — US disclosed
US-9593149-B2 Amylin and calcitonin receptor agonist NOVO NORDISK A/S (DK) 2017-03-14 — — US disclosed
EP-2910571-B1 PROTEASE STABILIZED, ACYLATED INSULIN ANALOGUES NOVO NORDISK AS (DK) 2016-10-05 — — EP disclosed
EP-2254906-B1 PROTEASE STABILIZED, ACYLATED INSULIN ANALOGUES NOVO NORDISK AS (DK) 2016-10-05 — — EP disclosed
US-20150148521-A1 INSULINS WITH AN ACYL MOIETY COMPRISING REPEATING UNITS OF ALKYLENE GLYCOL CONTAINING AMINO ACIDS NOVO NORDISK AS (DK) 2015-05-28 — — US disclosed
US-9035020-B1 Insulins with an acyl moiety comprising repeating units of alkylene glycol containing amino acids NOVO NORDISK A/S (DK) 2015-05-19 — — US disclosed
US-8962794-B2 Insulins with an acyl moiety comprising repeating units of alkylene glycol containing amino acids NOVO NORDISK A/S (DK) 2015-02-24 — — US disclosed
US-20140357838-A1 N-Terminally Modified Insulin Derivatives NOVO NORDISK A/S (DK) 2014-12-04 — — US disclosed
US-20140315797-A1 Novel N-Terminally Modified Insulin Derivatives NOVO NORDISK A/S (DK) 2014-10-23 — — US disclosed
US-20140073564-A1 PROTEASE STABILIZED, ACYLATED INSULIN ANALOGUES NOVO NORDISK A/S (DK) 2014-03-13 — — US disclosed
US-20110293714-A1 PHARMACEUTICAL COMPOSITIONS SUITABLE FOR ORAL ADMINISTRATION OF DERIVATIZED INSULIN PEPTIDES NOVO NORDISK A/S (DK) 2011-12-01 — — US disclosed
US-20110098439-A1 INSULINS WITH AN ACYL MOIETY COMPRISING REPEATING UNITS OF ALKYLENE GLYCOL CONTAINING AMINO ACIDS NOVO NORDISK A/S (DK) 2011-04-28 — — US disclosed
US-20110098440-A1 Insulin Analogues with an Acyl and Alkylene Glycol Moiety NOVO NORDISK A/S (DK) 2011-04-28 — — US disclosed
WO-2009022005-A1 INSULIN ANALOGUES WITH AN ACYL AND ALKYLENE GLYCOL MOIETY NOVO NORDISK A/S (DK) 2009-02-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140357838-A1 N-Terminally Modified Insulin Derivatives IAPP, INSR, PTMS GLP1R 12/4885NOD1 1067/4885CCKAR 649/4885
US-10174082-B2 Amylin and calcitonin receptor agonist CALCRL, SCTR, IAPP GLP1R 4/4885NOD1 485/4885CCKAR 59/4885
US-20140315797-A1 Novel N-Terminally Modified Insulin Derivatives IAPP, INSR, IRS1 GLP1R 12/4885NOD1 428/4885CCKAR 186/4885
US-20170145059-A1 Novel Amylin And Calcitonin Receptor Agonist SCTR, CALCRL, IAPP GLP1R 4/4885NOD1 445/4885CCKAR 45/4885
US-20110098440-A1 Insulin Analogues with an Acyl and Alkylene Glycol Moiety IAPP, INSR, IGF1R GLP1R 7/4885NOD1 3208/4885CCKAR 250/4885
US-20140073564-A1 PROTEASE STABILIZED, ACYLATED INSULIN ANALOGUES IAPP, IDE, LIPE GLP1R 84/4885NOD1 3929/4885CCKAR 1335/4885
US-20150148521-A1 INSULINS WITH AN ACYL MOIETY COMPRISING REPEATING UNITS OF ALKYLENE GLYCOL CONTAINING AMINO ACIDS IAPP, INSR, IGF1R GLP1R 19/4885NOD1 3838/4885CCKAR 413/4885
US-20110098439-A1 INSULINS WITH AN ACYL MOIETY COMPRISING REPEATING UNITS OF ALKYLENE GLYCOL CONTAINING AMINO ACIDS IAPP, INSR, IGF1R GLP1R 19/4885NOD1 3838/4885CCKAR 413/4885
US-20110293714-A1 PHARMACEUTICAL COMPOSITIONS SUITABLE FOR ORAL ADMINISTRATION OF DERIVATIZED INSULIN PEPTIDES IAPP, VIP, INSR GLP1R 4/4885NOD1 782/4885CCKAR 373/4885
US-20190112348-A1 PROTEASE STABILIZED, ACYLATED INSULIN ANALOGUES IAPP, IDE, LIPE GLP1R 84/4885NOD1 3929/4885CCKAR 1335/4885
US-10259856-B2 Protease stabilized acylated insulin analogues IAPP, IDE, LIPE GLP1R 54/4885NOD1 3835/4885CCKAR 1242/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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