SCHEMBL12809272

SCHEMBL12809272

CC(C)(C)c1ccc(N(c2ccc(-c3sc(-c4ccc(N(c5ccc(C(C)(C)C)cc5)c5ccc(C(C)(C)C)cc5)cc4)c([N+](=O)[O-])c3N)cc2)c2ccc(C(C)(C)C)cc2)cc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 4/20 0.35
RAB9A P51151 4/20 0.35
KDM4E B2RXH2 1/20 0.35
NPBWR1 P48145 1/20 0.32
ALDH1A1 P00352 3/20 0.32
MEN1 O00255 1/20 0.32
CRHBP P24387 1/20 0.32
KMT2A Q03164 1/20 0.32
ATM Q13315 1/20 0.32
CRHR2 Q13324 1/20 0.32
TLR9 Q9NR96 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
FBP1 P09467 1/20 0.32
HTT P42858 2/20 0.31
HSP90AA1 P07900 1/20 0.31
CASP7 P55210 1/20 0.31
CASP6 P55212 1/20 0.31
CASP8 Q14790 1/20 0.31
XBP1 P17861 1/20 0.31
LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14066320 0.91 ALDH1A1 (0.36) NPC1RAB9AKDM4ENPBWR1ALDH1A1
SCHEMBL14066318 0.73 ALDH1A1 (0.56) KDM4EALDH1A1MEN1CRHBPKMT2A
SCHEMBL21797206 0.72 MEN1 (0.39) NPC1RAB9AKDM4EALDH1A1MEN1
SCHEMBL12809276 0.68 TSHR (0.41) NPC1RAB9AALDH1A1MEN1CRHBP
SCHEMBL16343998 0.68 KIF11 (0.54) NPC1RAB9AKDM4EALDH1A1KMT2A
SCHEMBL8642413 0.68 KIF11 (0.54) NPC1RAB9AKDM4EALDH1A1KMT2A
SCHEMBL12951069 0.68 KIF11 (0.54) NPC1RAB9AKDM4EALDH1A1KMT2A
SCHEMBL6131669 0.67 ALDH1A1 (0.52) NPC1RAB9AKDM4EALDH1A1MEN1
SCHEMBL15573306 0.67 FBP1 (0.42) ALDH1A1FBP1TDP1
SCHEMBL14163841 0.66 TSHR (0.52) NPC1RAB9AALDH1A1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1680481-B1 NEW COMPOUND CAPABLE OF BEING USED IN ORGANIC LAYER OF ORGANIC LIGHT EMITTING DEVICE LG CHEMICAL LTD (KR) 2011-03-02 EP disclosed