Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12809767 | 0.87 | SYK (0.43) | CYP2C19MEN1CYP3A4CYP2C9KMT2A | |
| SCHEMBL27737544 | 0.83 | NSD2 (0.42) | ALDH1A1KMT2AKDM4EHRH1 | |
| SCHEMBL27886662 | 0.82 | ALDH1A1 (0.40) | ALDH1A1KMT2ALMNAKDM4E | |
| SCHEMBL3289895 | 0.80 | SMN1; SMN2 (0.41) | ALDH1A1LMNAKDM4E | |
| SCHEMBL16908724 | 0.78 | POLB (0.50) | ALDH1A1MEN1KMT2AKDM4EHTT | |
| SCHEMBL13293997 | 0.77 | LMNA (0.51) | ALDH1A1LMNAHTT | |
| SCHEMBL1407044 | 0.76 | POLB (0.50) | KDM4E | |
| SCHEMBL2521881 | 0.75 | CYP2C19 (0.51) | ALDH1A1CYP2C19MEN1KMT2AGAA | |
| SCHEMBL4718351 | 0.71 | PRKAB2 (0.35) | KMT2ALRRK2IRAK4 | |
| SCHEMBL1516751 | 0.71 | OPRK1 (0.55) | MEN1KMT2AMAPTROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1999114-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. Hoffmann-la Roche AG (CH) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007107470-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-27 | — | — | WO | disclosed |