SCHEMBL12815898

SCHEMBL12815898

Cc1cc([Si](Cl)(c2cc(C)c(Cc3ccccc3)c(Cc3ccccc3)c2)c2cc(C)c(Cc3ccccc3)c(Cc3ccccc3)c2)cc(Cc2ccccc2)c1Cc1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2 P10415 1/20 0.38
BCL2L1 Q07817 1/20 0.38
DRD4 P21917 1/20 0.36
DRD3 P35462 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
HPGD P15428 3/20 0.36
CYP3A4 P08684 2/20 0.36
MEN1 O00255 1/20 0.36
ALOX15 P16050 1/20 0.36
KMT2A Q03164 1/20 0.36
HIF1A Q16665 1/20 0.36
HSD17B10 Q99714 1/20 0.36
IDH1 O75874 1/20 0.36
CYP2D6 P10635 1/20 0.35
TSHR P16473 1/20 0.35
CYP2C19 P33261 1/20 0.35
CTRC Q99895 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
KDM4E B2RXH2 1/20 0.35
ALDH1A1 P00352 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12815239 0.90 HTR1D (0.40) HPGDMEN1KMT2AHSD17B10IDH1
SCHEMBL12816068 0.83 BCL2 (0.42) BCL2BCL2L1DRD4DRD3L3MBTL1
SCHEMBL12816218 0.80 CYP3A4 (0.40) BCL2BCL2L1HPGDCYP3A4MEN1
SCHEMBL12815566 0.80 CTRC (0.40) BCL2BCL2L1HPGDCYP3A4MEN1
SCHEMBL12815582 0.79 ADCY10 (0.37) BCL2BCL2L1HPGDCYP3A4MEN1
SCHEMBL12816356 0.79 BCL2 (0.37) BCL2BCL2L1HPGDCYP3A4MEN1
SCHEMBL12816078 0.76 BCL2 (0.37) BCL2BCL2L1HPGDCYP3A4MEN1
SCHEMBL12816993 0.76 BCL2 (0.37) BCL2BCL2L1HPGDCYP3A4MEN1
SCHEMBL12817536 0.76 CALM1 (0.39) HPGDMEN1KMT2AHSD17B10IDH1
SCHEMBL28009449 0.75 BCL2 (0.45) BCL2BCL2L1HPGDCYP3A4MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012133935-A1 METHOD FOR PRODUCING THE TRANSITION METAL COMPLEX, CATALYST FOR TRIMERIZATION, METHOD FOR PRODUCING 1-HEXENE, METHOD FOR PRODUCING THE SUBSTITUTED CYCLOPENTADIENE COMPOUND (3) SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-10-04 WO disclosed