Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 1/20 | 0.34 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12818293 | 0.83 | CPT2 (0.35) | MEN1KMT2AMAPTGCKALDH1A1 | |
| SCHEMBL12818652 | 0.83 | MEN1 (0.40) | MEN1KMT2ACYP2C9MAPTTP53 | |
| SCHEMBL12818134 | 0.82 | CYP2C9 (0.40) | MEN1KMT2ACYP2C9MAPTTP53 | |
| SCHEMBL12817846 | 0.82 | LMNA (0.43) | MEN1KMT2ACYP2C9MAPTTP53 | |
| SCHEMBL12818382 | 0.81 | MAPT (0.44) | MEN1KMT2ACYP2C9MAPTTP53 | |
| SCHEMBL12819192 | 0.80 | MEN1 (0.40) | MEN1KMT2ACYP2C9MAPTTP53 | |
| SCHEMBL12818698 | 0.79 | CYP2C9 (0.37) | MEN1KMT2ACYP2C9MAPTTP53 | |
| SCHEMBL12817667 | 0.79 | PGR (0.39) | MEN1KMT2ACYP2C9MAPTTP53 | |
| SCHEMBL12817769 | 0.79 | CYP2C9 (0.38) | MEN1KMT2ACYP2C9MAPTTP53 | |
| SCHEMBL12818506 | 0.78 | CYP2C9 (0.42) | MEN1KMT2ACYP2C9MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | disclosed |