Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 7/20 | 0.41 |
| ▸ | BRD2 | P25440 | 6/20 | 0.41 |
| ▸ | BRD3 | Q15059 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12817768 | 0.83 | BRD4 (0.40) | MAPTALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL12818708 | 0.82 | BRD4 (0.45) | MAPTALDH1A1BRD4BRD2BRD3 | |
| SCHEMBL12818110 | 0.81 | MAPT (0.45) | MAPTBRD4BRD2BRD3MEN1 | |
| SCHEMBL12818134 | 0.81 | CYP2C9 (0.40) | MAPTALDH1A1MEN1KMT2ACYP2C9 | |
| SCHEMBL12817618 | 0.81 | MEN1 (0.41) | MAPTALDH1A1MEN1KMT2ACYP2C9 | |
| SCHEMBL12818102 | 0.80 | BRD4 (0.45) | MAPTBRD4BRD2BRD3MEN1 | |
| SCHEMBL12818652 | 0.79 | MEN1 (0.40) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL12818698 | 0.79 | CYP2C9 (0.37) | MAPTALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL12817667 | 0.79 | PGR (0.39) | MAPTALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL12817769 | 0.79 | CYP2C9 (0.38) | MAPTALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | claimed |
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | disclosed |