Sugi Predict

Sugi Predict / Compounds / SCHEMBL1281771

SCHEMBL1281771

SCHEMBL1281771

OC(c1ccccc1)c1c[nH]nn1

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ LMNA P02545 5/20 0.35
▸ HPGD P15428 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ ALDH1A1 P00352 2/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ HTT P42858 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ MAPT P10636 1/20 0.33
▸ CYP2C9 P11712 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ TSHR P16473 2/20 0.32
▸ SLC2A1 P11166 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL1982282 0.98 SMN1; SMN2 (0.39) SMN1; SMN2LMNAHPGDKDM4EL3MBTL1
SCHEMBL13728553 0.81 CYP19A1 (0.31) —
SCHEMBL5865738 0.80 SLC6A2 (0.45) L3MBTL1ALDH1A1MAPTCYP2C9KMT2A
SCHEMBL7921340 0.78 CYP19A1 (0.32) TSHR
SCHEMBL9634376 0.78 L3MBTL1 (0.35) L3MBTL1MEN1KMT2A
SCHEMBL9525219 0.77 DPP4 (0.38) LMNA
SCHEMBL11344228 0.77 CES2 (0.32) L3MBTL1
SCHEMBL5764498 0.77 CES2 (0.32) ALDH1A1CYP2C9
SCHEMBL15437001 0.77 HTR2C (0.42) LMNAKDM4EMEN1KMT2A
SCHEMBL11351479 0.77 TSHR (0.38) HPGDKDM4EL3MBTL1ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 117 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12624051-B2 Macrocyclic compounds, compositions, and methods of using thereof GENZYME CORPORATION (US) 2026-05-12 — — US disclosed
US-20260008785-A1 MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF SCHRODINGER, LLC 2026-01-08 — — US disclosed
US-20260008786-A1 MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF SCHRODINGER, LLC 2026-01-08 — — US disclosed
US-20250197422-A1 MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF SCHRODINGER, LLC 2025-06-19 — — US disclosed
US-12016952-B2 Methods of preparing a monodisperse oligo(ethylene glycol) reagent composition NEKTAR THERAPEUTICS (US) 2024-06-25 — — US disclosed
WO-2024054840-A1 MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF SIONNA THERAPEUTICS (US) 2024-03-14 — — WO disclosed
CN-116650424-A Novel polypeptide formulations and therapeutic uses thereof 鸿绪生物医药科技（北京）有限公司 2023-08-29 — — CN disclosed
CN-112638426-B Aromatic nitro-based linker, antibody conjugated drug containing linker and use of linker 中国人民解放军军事科学院军事医学研究院 2023-06-16 — — CN disclosed
CN-110167599-B Compounds comprising self-sacrificing linking groups incorporating beta-galactosides 英托赛尔公司 2023-05-16 — — CN disclosed
CN-116133677-A Novel polypeptide formulations and therapeutic uses thereof 鸿绪生物医药科技（北京）有限公司 2023-05-16 — — CN disclosed
US-4368190-A IMMUNOADJUVANT MERCK & CO., INC. (US) 1983-01-11 — — US disclosed
EP-0018901-B1 IMMUNOLOGICALLY ACTIVE PEPTIDYL DISACCHARIDES, METHODS OF PREPARATION AND VACCINE MERCK & CO. INC. (US) 1982-12-15 — — EP disclosed
EP-0014159-B1 IMMUNOLOGICALLY ACTIVE DIPEPTIDYL SACCHARIDES AND METHODS OF PREPARATION MERCK & CO. INC. (US) 1982-07-14 — — EP disclosed
US-4315913-A BACTERICIDES, VIRICIDES, PARASITICIDES VACCINE MERCK & CO. INC. (US) 1982-02-16 — — US disclosed
US-4310514-A VACCINES MERCK & CO., INC. (US) 1982-01-12 — — US disclosed
EP-0041896-A1 Immunologically active dipeptidyl 2-amino-1,2-dideoxy-D-glucose derivatives and methods of preparation MERCK & CO. INC. (US) 1981-12-16 — — EP disclosed
EP-0039637-A1 Immunologically active dipeptidyl 5-0,6-0-acyl-2-amino-2-deoxy-D-glucofuranose derivatives and methods of preparation MERCK & CO. INC. (US) 1981-11-11 — — EP disclosed
EP-0038750-A1 Immunologically active dipeptidyl 4-0-, 6-0-acyl-2-amino-2-deoxy-D-glucose derivatives and methods for their preparation MERCK & CO. INC. (US) 1981-10-28 — — EP disclosed
US-4256735-A BACTERICIDES MERCK & CO., INC. (US) 1981-03-17 — — US disclosed
EP-0018901-A1 Immunologically active peptidyl disaccharides, methods of preparation and vaccine MERCK & CO. INC. (US) 1980-11-12 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12624051-B2 Macrocyclic compounds, compositions, and methods of using thereof CFTR, ABCC3, ABCD3 SMN1; SMN2 4138/4885LMNA 2583/4885HPGD 3089/4885
US-20260008786-A1 MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF CFTR, ABCC3, ABCD3 SMN1; SMN2 4138/4885LMNA 2583/4885HPGD 3089/4885
US-20260008785-A1 MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF CFTR, ABCC3, ABCD3 SMN1; SMN2 4069/4885LMNA 2664/4885HPGD 2824/4885
US-20250197422-A1 MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF CFTR, ABCB1, PKD1 SMN1; SMN2 3610/4885LMNA 2396/4885HPGD 1117/4885
US-12016952-B2 Methods of preparing a monodisperse oligo(ethylene glycol) reagent composition POLM, OGG1, COPE SMN1; SMN2 3911/4885LMNA 1270/4885HPGD 1020/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.