Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | PKLR | P30613 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CPT2 | P23786 | 2/20 | 0.33 |
| ▸ | CPT1A | P50416 | 2/20 | 0.33 |
| ▸ | CPT1B | Q92523 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12819192 | 0.83 | MEN1 (0.40) | KDM2BPKMPKLRTHRBLMNA | |
| SCHEMBL12817661 | 0.81 | PKM (0.43) | KDM2BPKMPKLRTHRBLMNA | |
| SCHEMBL12817919 | 0.81 | BRD4 (0.41) | KDM2BPKMPKLRGPR119 | |
| SCHEMBL12818569 | 0.80 | PKM (0.42) | KDM2BPKMPKLRLMNACPT2 | |
| SCHEMBL12818293 | 0.80 | CPT2 (0.35) | PKMLMNACPT2CPT1ACPT1B | |
| SCHEMBL12817651 | 0.80 | PKM (0.43) | KDM2BPKMPKLRTHRBLMNA | |
| SCHEMBL12818592 | 0.79 | HTR6 (0.40) | KDM2BPKMPKLRTHRBLMNA | |
| SCHEMBL12817855 | 0.79 | KDM2B (0.37) | KDM2BPKMPKLRTHRBLMNA | |
| SCHEMBL12817775 | 0.79 | GAA (0.40) | PKMCPT2CPT1ACPT1BCNR1 | |
| SCHEMBL12817886 | 0.78 | PKM (0.41) | KDM2BPKMPKLRTHRBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | claimed |
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | disclosed |