Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 12/20 | 0.40 |
| ▸ | BRD2 | P25440 | 9/20 | 0.40 |
| ▸ | BRD3 | Q15059 | 9/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CPT2 | P23786 | 1/20 | 0.35 |
| ▸ | CPT1A | P50416 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12818382 | 0.83 | MAPT (0.44) | BRD4BRD2BRD3ALDH1A1MAPT | |
| SCHEMBL12818772 | 0.83 | BRD4 (0.45) | BRD4BRD2BRD3ALDH1A1DRD2 | |
| SCHEMBL12817919 | 0.82 | BRD4 (0.41) | BRD4BRD2BRD3DRD2HTR2A | |
| SCHEMBL12817890 | 0.82 | HSPD1 (0.40) | DRD2HTR2AHTR2CDRD3HTR6 | |
| SCHEMBL12818293 | 0.81 | CPT2 (0.35) | ALDH1A1MAPTHPGDALOX15HSD17B10 | |
| SCHEMBL12817711 | 0.80 | GCK (0.36) | ALDH1A1MAPTHPGDALOX15HSD17B10 | |
| SCHEMBL12818910 | 0.80 | BRD4 (0.44) | BRD4BRD2BRD3DRD2HTR2A | |
| SCHEMBL12818272 | 0.80 | GCK (0.35) | ALDH1A1MAPTHPGDALOX15HSD17B10 | |
| SCHEMBL12819156 | 0.80 | PGR (0.39) | ALDH1A1MAPTHPGDALOX15HSD17B10 | |
| SCHEMBL12818288 | 0.76 | BRD4 (0.42) | BRD4BRD2BRD3DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | claimed |
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | disclosed |