Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | PKLR | P30613 | 1/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | LGMN | Q99538 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | PRF1 | P14222 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | PGR | P06401 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12818419 | 0.86 | HTR6 (0.40) | PKMPKLRKDM2BTHRBLMNA | |
| SCHEMBL12818423 | 0.85 | CYP11B1 (0.39) | PKMLMNAHTR6PGR | |
| SCHEMBL12818475 | 0.83 | PKM (0.38) | PKMPKLRKDM2BTHRBLMNA | |
| SCHEMBL12818563 | 0.82 | PGR (0.32) | PGR | |
| SCHEMBL12819210 | 0.82 | PKM (0.38) | PKMPKLRKDM2BTHRBLMNA | |
| SCHEMBL12818401 | 0.81 | PKM (0.37) | PKMPKLRKDM2BTHRBLMNA | |
| SCHEMBL12818905 | 0.81 | CYP11B1 (0.35) | KDM2BLMNAHTR6PGR | |
| SCHEMBL12818566 | 0.81 | CYP11B1 (0.35) | KDM2BHTR6PGR | |
| SCHEMBL12818398 | 0.81 | PKM (0.36) | PKMPKLRKDM2BTHRBLMNA | |
| SCHEMBL12818451 | 0.80 | GCK (0.39) | PGRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | claimed |
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | disclosed |