Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.45 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | PKLR | P30613 | 1/20 | 0.42 |
| ▸ | BRD2 | P25440 | 6/20 | 0.40 |
| ▸ | BRD3 | Q15059 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CPT2 | P23786 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12817923 | 0.85 | LMNA (0.47) | KDM2BPKMPKLRLMNAALDH1A1 | |
| SCHEMBL12818708 | 0.84 | BRD4 (0.45) | BRD4KDM2BPKMPKLRBRD2 | |
| SCHEMBL12818367 | 0.83 | PKM (0.45) | KDM2BPKMPKLRLMNAALDH1A1 | |
| SCHEMBL12817768 | 0.83 | BRD4 (0.40) | BRD4BRD2BRD3LMNAALDH1A1 | |
| SCHEMBL12818308 | 0.82 | PKM (0.43) | KDM2BPKMPKLRLMNAALDH1A1 | |
| SCHEMBL12818524 | 0.82 | PKM (0.44) | KDM2BPKMPKLRLMNAALDH1A1 | |
| SCHEMBL12818150 | 0.82 | PKM (0.44) | KDM2BPKMPKLRLMNAALDH1A1 | |
| SCHEMBL12818462 | 0.82 | PKM (0.46) | KDM2BPKMPKLRLMNAALDH1A1 | |
| SCHEMBL12818495 | 0.82 | PKM (0.44) | KDM2BPKMPKLRLMNAALDH1A1 | |
| SCHEMBL12817919 | 0.82 | BRD4 (0.41) | BRD4KDM2BPKMPKLRBRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | claimed |
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | disclosed |