Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | CD38 | P28907 | 3/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12304066 | 0.84 | CYP11B1 (0.36) | CYP11B1CYP11B2ACLYSLC6A3SLC6A2 | |
| SCHEMBL9285177 | 0.77 | IDO1 (0.42) | IMPDH2IDO1ALOX5APFEN1 | |
| SCHEMBL28273968 | 0.75 | CYP11B1 (0.43) | CYP11B1CYP11B2ACLYIMPDH2CHEK1 | |
| SCHEMBL12820088 | 0.74 | GABRA1 (0.44) | — | |
| SCHEMBL21052234 | 0.74 | ABL1 (0.39) | CYP11B1CYP11B2IMPDH2CHEK1CHEK2 | |
| SCHEMBL10185913 | 0.73 | GRIN2B (0.34) | SLC6A3SLC6A2 | |
| SCHEMBL22193254 | 0.72 | TDO2 (0.50) | ALOX5APFEN1ABL1 | |
| SCHEMBL22871207 | 0.70 | MAPK14 (0.47) | CYP11B1CYP11B2 | |
| SCHEMBL7915410 | 0.68 | CD38 (0.49) | CYP11B1CYP11B2SLC6A3SLC6A2CD38 | |
| SCHEMBL26383338 | 0.67 | PARK7 (0.39) | IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011032277-A1 | QUINAZOLINONE DERIVATIVES AS VIRAL POLYMERASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-03-24 | — | — | WO | disclosed |