Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12850045 | 0.78 | MAPT (0.41) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL13002998 | 0.75 | MAPT (0.52) | MAPTGAAMEN1KMT2AL3MBTL1 | |
| SCHEMBL7897889 | 0.73 | MAPT (0.57) | MAPTGAAMEN1KMT2AL3MBTL1 | |
| SCHEMBL11025738 | 0.72 | CYP1A2 (0.50) | MAPTGAAMEN1KMT2AL3MBTL1 | |
| SCHEMBL5000599 | 0.72 | ALOX15 (0.50) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL16983107 | 0.71 | MAPK1 (0.55) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL1629235 | 0.71 | POLQ (0.48) | MAPTHTTCYP1A2CYP2C19CYP3A4 | |
| SCHEMBL4659391 | 0.71 | MAPT (0.48) | MAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL28091743 | 0.71 | PDK1 (0.69) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL13713255 | 0.71 | GRM5 (0.56) | MAPTHTTGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011035417-A1 | HSP-90 BINDING COMPOUNDS, COMPOSITIONS THEREOF, AND THEIR USE FN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES | AEGERA THERAPEUTICS INC. (CA) | 2011-03-31 | — | — | WO | disclosed |