Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 13/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13712796 | 0.80 | GRM5 (0.45) | GRM5CA2CA9MAPTHTT | |
| SCHEMBL14262899 | 0.77 | CA2 (0.44) | GRM5CA2CA9MAPT | |
| SCHEMBL5000599 | 0.74 | ALOX15 (0.50) | GRM5MAPTHSD17B10 | |
| SCHEMBL4077057 | 0.72 | GRM5 (0.69) | GRM5 | |
| SCHEMBL6714259 | 0.71 | ACHE (0.49) | GRM5MAPTHTTSMN1; SMN2 | |
| SCHEMBL12820475 | 0.71 | MAPT (0.45) | GRM5MAPTHTT | |
| SCHEMBL28091743 | 0.68 | PDK1 (0.69) | MAPT | |
| SCHEMBL4069253 | 0.68 | GRM5 (1.00) | GRM5 | |
| SCHEMBL30255585 | 0.68 | GRM5 (1.00) | GRM5CA9 | |
| SCHEMBL30879625 | 0.68 | GRM5 (1.00) | GRM5CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582771-B2 | Process for the synthesis of cPLA2 inhibitors | WYETH (US) | 2009-09-01 | — | — | US | disclosed |