Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.49 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | GLS | O94925 | 1/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16752130 | 0.98 | MAPT (0.52) | MAPTKDM4ECYP19A1TBXAS1LOXL2 | |
| SCHEMBL2592802 | 0.85 | LOXL2 (0.64) | MAPTKDM4ELOXL2CYP3A4LMNA | |
| SCHEMBL30200129 | 0.85 | LOXL2 (0.64) | MAPTKDM4ELOXL2CYP3A4LMNA | |
| Benzene SCHEMBL6631416 | 0.83 | LOXL2 (0.62) | MAPTKDM4ELOXL2CYP3A4LMNA | |
| Hydrochloric Acid SCHEMBL8762058 | 0.83 | LOXL2 (0.62) | MAPTKDM4ELOXL2CYP3A4LMNA | |
| Bromide SCHEMBL15618161 | 0.83 | LOXL2 (0.62) | MAPTKDM4ELOXL2CYP3A4LMNA | |
| SCHEMBL3136413 | 0.81 | KDM4E (0.56) | MAPTKDM4ECYP19A1TBXAS1LOXL2 | |
| SCHEMBL12992933 | 0.79 | MAPT (0.54) | MAPTKDM4ECYP19A1TBXAS1LOXL2 | |
| SCHEMBL6629717 | 0.79 | MAPT (0.54) | MAPTKDM4ECYP19A1TBXAS1LOXL2 | |
| SCHEMBL3817705 | 0.79 | MAPT (0.54) | MAPTKDM4ECYP19A1TBXAS1LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11332459-B2 | Benzimidazole derivatives and their uses | TEIJIN PHARMA LIMITED (JP) | 2022-05-17 | — | — | US | disclosed |
| US-20200308145-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USES | AMGEN INC. (US) | 2020-10-01 | — | — | US | disclosed |
| US-10660898-B2 | Benzimidazole derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2020-05-26 | — | — | US | disclosed |
| US-20190255064-A1 | BENZIMIDAZOLE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC | 2019-08-22 | — | — | US | disclosed |
| US-10314845-B2 | Benzimidazole derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2019-06-11 | — | — | US | disclosed |
| EP-3170813-B1 | BENZIMIDAZOLE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2018-12-12 | — | — | EP | disclosed |
| US-20180263994-A1 | Benzimidazole Derivatives as PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC | 2018-09-20 | — | — | US | disclosed |
| US-9872860-B2 | Benzimidazole derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2018-01-23 | — | — | US | disclosed |
| EP-3170813-A1 | BENZIMIDAZOLE DERIVATIVES AS PI3 KINASE INHIBITORS | Glaxosmithkline LLC (US) | 2017-05-24 | — | — | EP | disclosed |
| US-20170112844-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC | 2017-04-27 | — | — | US | disclosed |
| US-20140018534-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC (US) | 2014-01-16 | — | — | US | disclosed |
| US-8541411-B2 | Benzimidazole derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2013-09-24 | — | — | US | disclosed |
| EP-2624696-A1 | BENZIMIDAZOLE DERIVATIVES AS PI3 KINASE INHIBITORS | GlaxoSmithKline LLC (US) | 2013-08-14 | — | — | EP | disclosed |
| US-20130196990-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC | 2013-08-01 | — | — | US | disclosed |
| US-20130197221-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC (US) | 2013-08-01 | — | — | US | disclosed |
| CN-103124496-A | Benzimidazole derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC | 2013-05-29 | — | — | CN | disclosed |
| US-8435988-B2 | Benzimidazole derivatives as P13 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2013-05-07 | — | — | US | disclosed |
| US-20120088767-A1 | BENZIMIDAZOLE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC | 2012-04-12 | — | — | US | disclosed |
| WO-2012047538-A1 | BENZIMIDAZOLE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-04-12 | — | — | WO | disclosed |
| EP-0318225-A2 | 6-Aryl aminomethyl quinoline derivatives and their use as anti-tumour agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-05-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170112844-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | PI4KB, PIK3CD, PI4KA | MAPT 3380/4885KDM4E 2969/4885CYP19A1 1650/4885 |
| US-20180263994-A1 | Benzimidazole Derivatives as PI3 Kinase Inhibitors | PI4KB, PIK3CD, PI4KA | MAPT 3380/4885KDM4E 2969/4885CYP19A1 1650/4885 |
| US-20140018534-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | PI4KB, PIK3CD, PI4KA | MAPT 3347/4885KDM4E 2943/4885CYP19A1 1733/4885 |
| US-20200308145-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USES | TRPC6, TRPV6, TRPM6 | MAPT 3674/4885KDM4E 2263/4885CYP19A1 4477/4885 |
| US-20120088767-A1 | BENZIMIDAZOLE DERIVATIVES AS PI3 KINASE INHIBITORS | PI4KB, PI4KA, PIK3CD | MAPT 3376/4885KDM4E 2861/4885CYP19A1 1636/4885 |
| US-10660898-B2 | Benzimidazole derivatives as PI3 kinase inhibitors | PI4KB, PIK3CD, PI4KA | MAPT 3380/4885KDM4E 2969/4885CYP19A1 1650/4885 |
| US-20130196990-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | PI4KB, PIK3CD, PI4KA | MAPT 3380/4885KDM4E 2969/4885CYP19A1 1650/4885 |
| US-10314845-B2 | Benzimidazole derivatives as PI3 kinase inhibitors | PI4KB, PIK3CD, PI4KA | MAPT 3380/4885KDM4E 2969/4885CYP19A1 1650/4885 |
| US-11332459-B2 | Benzimidazole derivatives and their uses | TRPC6, TRPV6, TRPM6 | MAPT 3674/4885KDM4E 2263/4885CYP19A1 4477/4885 |
| US-20130197221-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | PI4KB, PIK3CD, PI4KA | MAPT 3380/4885KDM4E 2969/4885CYP19A1 1650/4885 |
| US-20190255064-A1 | BENZIMIDAZOLE DERIVATIVES AS PI3 KINASE INHIBITORS | PI4KB, PIK3CD, PI4KA | MAPT 3380/4885KDM4E 2969/4885CYP19A1 1650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.