Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13362121 | 0.85 | ALDH1A1 (0.61) | ALDH1A1MAPTARTSHRTDP1 | |
| SCHEMBL1746106 | 0.80 | ALDH1A1 (0.67) | ALDH1A1MAPTTSHRSMN1; SMN2MEN1 | |
| SCHEMBL20274100 | 0.79 | ALDH1A1 (0.57) | ALDH1A1MAPTARTSHRTDP1 | |
| SCHEMBL10100726 | 0.78 | DRD2 (0.42) | ALDH1A1MAPTARSMN1; SMN2GFER | |
| SCHEMBL393596 | 0.77 | ALDH1A1 (0.63) | ALDH1A1MAPTSMN1; SMN2HTTGFER | |
| SCHEMBL2206444 | 0.76 | ALDH1A1 (0.67) | ALDH1A1MAPTARTDP1SMN1; SMN2 | |
| SCHEMBL394896 | 0.76 | MAPT (1.00) | ALDH1A1MAPTSMN1; SMN2GFERHTR2B | |
| SCHEMBL2267850 | 0.76 | MAPT (0.67) | ALDH1A1MAPTTSHRTDP1MEN1 | |
| SCHEMBL2207168 | 0.76 | ALDH1A1 (0.61) | ALDH1A1MAPTTDP1MEN1KMT2A | |
| SCHEMBL27690269 | 0.76 | ALDH1A1 (0.61) | ALDH1A1MAPTARTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090131492-A1 | Indole derivatives as CFTR modulators | VERTEX PHARMACEUTICALS INCORPORATED | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131492-A1 | Indole derivatives as CFTR modulators | CFTR, ABCB1, ABCB11 | ALDH1A1 1620/4885MAPT 4528/4885AR 2074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.