Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.37 |
| ▸ | CDK9 | P50750 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12825025 | 0.93 | SMO (0.48) | SMOPHGDHCCR8HSD17B10EPHX2 | |
| SCHEMBL12825028 | 0.88 | TSHR (0.41) | USP2TSHRSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL12825027 | 0.86 | SMO (0.43) | SMOSMN1; SMN2ALDH1A1PHGDHEPHX2 | |
| SCHEMBL10003793 | 0.85 | SMO (0.49) | SMOUSP2TSHRSMN1; SMN2KMT2A | |
| SCHEMBL12825060 | 0.85 | SMO (0.43) | SMOKMT2AMEN1ALDH1A1EPHX2 | |
| SCHEMBL16588412 | 0.84 | SMO (0.42) | SMOCCNT1CDK9 | |
| SCHEMBL12825026 | 0.82 | SMO (0.43) | SMOSMN1; SMN2CCR8EPHX2HTT | |
| SCHEMBL12824618 | 0.81 | SMO (0.50) | SMOKMT2AMEN1POLBCCR8 | |
| SCHEMBL12825070 | 0.81 | NPSR1 (0.39) | KMT2AMEN1CCR8 | |
| SCHEMBL12824722 | 0.80 | SMO (0.43) | SMOEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011024869-A1 | FUSED HETEROCYCLIC RING DERIVATIVE AND USE THEREOF | 武田薬品工業株式会社 (JP) | 2011-03-03 | — | — | WO | disclosed |