Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | DVL1 | O14640 | 1/20 | 0.37 |
| ▸ | DVL3 | Q92997 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CDK14 | O94921 | 1/20 | 0.37 |
| ▸ | CCNY | Q8ND76 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12824871 | 0.93 | SMO (0.52) | SMOEPHX2MCL1CCR8MEN1 | |
| SCHEMBL12825025 | 0.87 | SMO (0.48) | SMOEPHX2CCR8CDK14CCNY | |
| SCHEMBL10003149 | 0.84 | SMO (0.49) | SMOEPHX2CCR8MEN1KMT2A | |
| SCHEMBL10003787 | 0.84 | SMO (0.60) | SMOEPHX2CCR8MEN1KMT2A | |
| SCHEMBL12824595 | 0.81 | SMO (0.41) | SMOEPHX2CCR8MEN1KMT2A | |
| SCHEMBL10293262 | 0.80 | SMO (0.53) | SMOEPHX2CCR8 | |
| SCHEMBL12825027 | 0.80 | SMO (0.43) | SMOEPHX2 | |
| SCHEMBL12824597 | 0.79 | NPSR1 (0.42) | SMOCCR8MEN1KMT2APOLB | |
| SCHEMBL12825060 | 0.79 | SMO (0.43) | SMOEPHX2MEN1KMT2A | |
| SCHEMBL10003405 | 0.79 | SMO (0.52) | SMOEPHX2CCR8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011024869-A1 | FUSED HETEROCYCLIC RING DERIVATIVE AND USE THEREOF | 武田薬品工業株式会社 (JP) | 2011-03-03 | — | — | WO | disclosed |