Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 8/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16070622 | 0.86 | SMO (0.50) | SMOALKPTK2TTK | |
| SCHEMBL12825025 | 0.86 | SMO (0.48) | SMOIRAK4 | |
| SCHEMBL12824595 | 0.84 | SMO (0.41) | SMOCCNT1CDK9 | |
| SCHEMBL10002829 | 0.80 | SMO (0.53) | SMOALKPTK2 | |
| SCHEMBL12825023 | 0.80 | SMO (0.42) | SMOALKTYRO3 | |
| SCHEMBL12824727 | 0.79 | SMO (0.45) | SMOIRAK4 | |
| SCHEMBL12825061 | 0.79 | SMO (0.46) | SMO | |
| SCHEMBL12825060 | 0.78 | SMO (0.43) | SMO | |
| SCHEMBL12824722 | 0.77 | SMO (0.43) | SMOIRAK4 | |
| SCHEMBL12824594 | 0.77 | SMO (0.43) | SMOCCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2471789-B9 | FUSED HETEROCYCLIC RING DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2015-03-25 | — | — | EP | disclosed |