Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.45 |
| ▸ | ULK1 | O75385 | 4/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | CDC7 | O00311 | 2/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.40 |
| ▸ | PAK4 | O96013 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CLK2 | P49760 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | PRKX | P51817 | 2/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | MELK | Q14680 | 2/20 | 0.40 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.40 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12826078 | 0.90 | ROCK2 (0.44) | TTKROCK2ULK1LRRK2MAPK1 | |
| SCHEMBL12825311 | 0.89 | ROCK2 (0.53) | TTKROCK2ULK1MAPK1CDC7 | |
| SCHEMBL12826136 | 0.87 | TTK (0.50) | TTKROCK2ULK1MAPK1CDC7 | |
| SCHEMBL12825520 | 0.80 | JAK2 (0.59) | TTKROCK2ULK1MAPK1CDC7 | |
| SCHEMBL12825525 | 0.79 | GSK3B (0.56) | TTKROCK2ULK1MAPK1CDC7 | |
| SCHEMBL12825861 | 0.77 | ROCK2 (0.57) | TTKROCK2ULK1MAPK1CDC7 | |
| SCHEMBL12825860 | 0.77 | ROCK2 (0.57) | TTKROCK2ULK1MAPK1CDC7 | |
| SCHEMBL12825406 | 0.77 | TTK (0.66) | TTKROCK2PLK4CHEK2AURKB | |
| SCHEMBL12826120 | 0.77 | ROCK2 (0.47) | TTKROCK2ULK1MAPK1CDC7 | |
| SCHEMBL12826077 | 0.77 | ULK1 (0.46) | TTKROCK2ULK1MAPK1CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295413-A1 | Indazole compounds useful as protein kinase inhibitors | Vertex Pharmaceuticals Incorporated (US) | 2011-03-16 | — | — | EP | disclosed |