Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.83 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.83 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.58 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 2/20 | 0.51 |
| ▸ | NQO2 | P16083 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | TTR | P02766 | 1/20 | 0.51 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | BCR | P11274 | 1/20 | 0.51 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.51 |
| ▸ | TUBB | P07437 | 1/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3392246 | 0.91 | PTGS2 (1.00) | PTGS2PTGS1TLR9CYP19A1NFE2L2 | |
| SCHEMBL4735253 | 0.91 | PTGS2 (1.00) | PTGS2PTGS1TLR9CYP19A1NFE2L2 | |
| SCHEMBL4733440 | 0.91 | PTGS2 (1.00) | PTGS2PTGS1TLR9CYP19A1NFE2L2 | |
| SCHEMBL3395077 | 0.84 | PTGS2 (0.86) | PTGS2PTGS1TLR9CYP19A1NFE2L2 | |
| SCHEMBL1005735 | 0.82 | PTGS2 (0.78) | PTGS2PTGS1TLR9CYP19A1NFE2L2 | |
| SCHEMBL1005734 | 0.82 | PTGS2 (0.78) | PTGS2PTGS1TLR9CYP19A1NFE2L2 | |
| SCHEMBL12535856 | 0.81 | PTGS2 (0.78) | PTGS2PTGS1CYP19A1ESR1NQO2 | |
| SCHEMBL10312395 | 0.81 | RELA (0.68) | PTGS2PTGS1CYP19A1ESR1NQO2 | |
| SCHEMBL1405456 | 0.81 | PTGS2 (0.75) | PTGS2PTGS1TLR9CYP19A1NFE2L2 | |
| SCHEMBL1405454 | 0.81 | PTGS2 (0.75) | PTGS2PTGS1TLR9CYP19A1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2289504-A2 | SIRT1 modulators for manipulating cell/organism lifespan/stress response | President and Fellows of Harvard College (US) | 2011-03-02 | — | — | EP | disclosed |