Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.35 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12834192 | 0.86 | MAPK14 (0.47) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL14090786 | 0.86 | ACSS2 (0.42) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL12833757 | 0.85 | SMN1; SMN2 (0.45) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL12833745 | 0.84 | SMN1; SMN2 (0.47) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL1509532 | 0.84 | CARM1 (0.43) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL12833879 | 0.82 | HDAC6 (0.41) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL12833424 | 0.82 | PDE10A (0.44) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL12834499 | 0.82 | HPGDS (0.43) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL12833953 | 0.81 | TBK1 (0.46) | CARM1TBK1GSK3BSMN1; SMN2 | |
| SCHEMBL12833445 | 0.81 | CARM1 (0.47) | HDAC3HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298770-A1 | Heterocyclic compounds as TrkA modulators | ChemBridge Corporation (US) | 2011-03-23 | — | — | EP | disclosed |