Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | SCD | O00767 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9963313 | 0.85 | HRH3 (0.52) | ADRA1DADRA1AADRA1BHRH3SIGMAR1 | |
| SCHEMBL7330399 | 0.80 | SIGMAR1 (0.67) | ADRA1DADRA1AADRA1BHRH3SIGMAR1 | |
| SCHEMBL650480 | 0.79 | ADRA1D (0.47) | ADRA1DADRA1AADRA1BHRH3SIGMAR1 | |
| SCHEMBL30541946 | 0.79 | ADRA1D (0.47) | ADRA1DADRA1AADRA1BHRH3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL20954914 | 0.79 | SIGMAR1 (0.65) | ADRA1DADRA1AADRA1BHRH3SIGMAR1 | |
| SCHEMBL742078 | 0.78 | SIGMAR1 (0.65) | ADRA1DADRA1AADRA1BHRH3SIGMAR1 | |
| SCHEMBL2743253 | 0.78 | KMT2A (0.49) | ADRA1DADRA1AADRA1BSIGMAR1HTR2A | |
| SCHEMBL19852497 | 0.78 | HRH3 (0.53) | ADRA1DADRA1AADRA1BHRH3POLB | |
| Hydrochloric Acid SCHEMBL16496302 | 0.77 | ADRA1D (0.46) | ADRA1DADRA1AADRA1BHRH3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL31150738 | 0.77 | ADRA1D (0.46) | ADRA1DADRA1AADRA1BHRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230355609-A1 | Spirolactone Compounds | QUIXGEN, INC. (US) | 2023-11-09 | — | — | US | disclosed |
| EP-2023924-B1 | ARYL-FUSED SPIROCYCLIC COMPOUNDS | MERCK SHARP & DOHME (US) | 2016-08-03 | — | — | EP | disclosed |
| WO-2011025690-A1 | NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2011-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230355609-A1 | Spirolactone Compounds | ACACA, AKR1C2, AKR1A1 | ADRA1D 766/4885ADRA1A 688/4885ADRA1B 687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.