SCHEMBL12839629

SCHEMBL12839629

CCCc1nc(-c2ccc(OC)cc2)cnc1NC(=O)Cc1ccc(O)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTOR P42345 1/20 0.46
ALDH1A1 P00352 4/20 0.45
KMT2A Q03164 3/20 0.45
MAPT P10636 3/20 0.45
MEN1 O00255 2/20 0.45
ROCK1 Q13464 1/20 0.45
APP P05067 1/20 0.45
WNT3A P56704 2/20 0.44
HTT P42858 1/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
KDM4E B2RXH2 2/20 0.44
NPC1 O15118 2/20 0.44
HPGD P15428 2/20 0.44
RAB9A P51151 2/20 0.44
ADRB2 P07550 1/20 0.44
LMNA P02545 1/20 0.44
MAPK8 P45983 1/20 0.44
NLRP3 Q96P20 1/20 0.43
ADRB1 P08588 1/20 0.43
ADRB3 P13945 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12839097 0.93 ROCK1 (0.44) KMT2AMAPTMEN1ROCK1WNT3A
SCHEMBL12839630 0.91 ALDH1A1 (0.45) ALDH1A1KMT2AMAPTMEN1ROCK1
SCHEMBL12839633 0.91 TP53 (0.48) ALDH1A1KMT2AMAPTMEN1ROCK1
SCHEMBL12839631 0.91 ALDH1A1 (0.46) ALDH1A1KMT2AMAPTMEN1ROCK1
SCHEMBL12839635 0.91 MEN1 (0.50) ALDH1A1KMT2AMAPTMEN1ROCK1
SCHEMBL12840059 0.91 ALDH1A1 (0.51) ALDH1A1KMT2AMAPTMEN1APP
SCHEMBL12840420 0.88 KMT2A (0.47) ALDH1A1KMT2AMEN1ROCK1WNT3A
SCHEMBL12839102 0.88 RORC (0.44) KMT2AMEN1ROCK1NPC1RAB9A
SCHEMBL12839056 0.88 MAPK1 (0.41) KMT2AMAPTMEN1ROCK1WNT3A
SCHEMBL12839104 0.88 KMT2A (0.47) ALDH1A1KMT2AMEN1ROCK1WNT3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110070656-A1 Fluorescent Proteins JNC CORPORATION (JP) 2011-03-24 US disclosed
EP-1666488-B1 FLUORESCENT PROTEIN CHISSO CORP (JP) 2010-11-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110070656-A1 Fluorescent Proteins CACYBP, CHLSN, LCP2 MTOR 4825/4885ALDH1A1 4516/4885KMT2A 4653/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.