SCHEMBL12839632

SCHEMBL12839632

CCCc1nc(-c2ccc(OC)cc2)cnc1NC(=O)Cc1ccc(F)c(F)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.52
MEN1 O00255 5/20 0.52
RAB9A P51151 3/20 0.44
WNT3A P56704 2/20 0.42
MAPK8 P45983 1/20 0.41
MAPT P10636 2/20 0.41
POLB P06746 1/20 0.41
ALDH1A1 P00352 4/20 0.41
ROCK1 Q13464 3/20 0.41
VNN1 O95497 1/20 0.41
APP P05067 1/20 0.41
KDM4E B2RXH2 2/20 0.41
NPC1 O15118 2/20 0.41
HPGD P15428 2/20 0.41
CYP3A4 P08684 2/20 0.41
ROCK2 O75116 1/20 0.41
PRKACA P17612 1/20 0.41
ADORA3 P0DMS8 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
ADRB2 P07550 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12838980 0.93 KMT2A (0.54) KMT2AMEN1RAB9AWNT3AMAPK8
SCHEMBL12839633 0.90 TP53 (0.48) KMT2AMEN1RAB9AWNT3AMAPK8
SCHEMBL12839106 0.90 CACNA1H (0.41) KMT2AMEN1RAB9AWNT3AMAPK8
SCHEMBL12839071 0.89 CACNA1H (0.40) KMT2AMEN1RAB9AWNT3AMAPK8
SCHEMBL12840377 0.89 CACNA1H (0.41) KMT2AMEN1RAB9AWNT3ANPC1
SCHEMBL12838532 0.88 KMT2A (0.52) KMT2AMEN1RAB9AWNT3AMAPK8
SCHEMBL12838484 0.88 RIOK2 (0.52) KMT2AMEN1RAB9AWNT3AMAPK8
SCHEMBL12839635 0.88 MEN1 (0.50) KMT2AMEN1RAB9AWNT3AMAPT
SCHEMBL12840071 0.87 KMT2A (0.56) KMT2AMEN1RAB9AWNT3AMAPT
SCHEMBL12839629 0.87 MTOR (0.46) KMT2AMEN1RAB9AWNT3AMAPK8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110070656-A1 Fluorescent Proteins JNC CORPORATION (JP) 2011-03-24 US disclosed
EP-1666488-B1 FLUORESCENT PROTEIN CHISSO CORP (JP) 2010-11-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110070656-A1 Fluorescent Proteins CACYBP, CHLSN, LCP2 KMT2A 4653/4885MEN1 3926/4885RAB9A 2980/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.