Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 6/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12846921 | 0.88 | KDM4E (0.39) | SMN1; SMN2ALDH1A1CYP1A2KDM4EMEN1 | |
| SCHEMBL12788840 | 0.87 | KMT2A (0.44) | BRD4SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL12789870 | 0.81 | CHRM2 (0.35) | BRD4NPSR1SMN1; SMN2SLC6A2SLC6A4 | |
| SCHEMBL12789107 | 0.81 | CYP2D6 (0.43) | — | |
| SCHEMBL12788843 | 0.80 | POLB (0.38) | BRD4SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL12846928 | 0.80 | KDM4E (0.41) | SMN1; SMN2ALDH1A1CYP1A2KDM4EMEN1 | |
| SCHEMBL12847381 | 0.78 | POLB (0.47) | SMN1; SMN2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL12846924 | 0.78 | KDM4E (0.37) | SMN1; SMN2ALDH1A1CYP1A2KDM4EMEN1 | |
| SCHEMBL12846922 | 0.76 | MEN1 (0.39) | SMN1; SMN2SLC6A2SLC6A4ALDH1A1CYP1A2 | |
| SCHEMBL12788312 | 0.74 | KDM4E (0.50) | SMN1; SMN2ALDH1A1CYP1A2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297117-B1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | MERCK SHARP & DOHME (US) | 2012-10-31 | — | — | EP | disclosed |
| US-20110065671-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | MERCK SHARP & DOHME CORP. | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065671-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | GPR119, GPR39, GPR65 | BRD4 563/4885NPSR1 179/4885SMN1; SMN2 4114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.