Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12846921 | 0.86 | KDM4E (0.39) | KDM4EMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL12789450 | 0.85 | KMT2A (0.48) | KDM4EMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL12846922 | 0.81 | MEN1 (0.39) | KDM4EMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL12789878 | 0.79 | PDE3B (0.35) | KDM4EMEN1KMT2AALDH1A1POLB | |
| SCHEMBL12847303 | 0.78 | BRD4 (0.37) | KDM4EMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL12788882 | 0.78 | POLB (0.41) | KDM4EMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL12846928 | 0.77 | KDM4E (0.41) | KDM4EMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL13564442 | 0.76 | KDM4E (0.40) | KDM4EMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL13564427 | 0.76 | KMT2A (0.47) | KDM4EMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL12847381 | 0.75 | POLB (0.47) | KDM4EMEN1KMT2AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110065671-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | MERCK SHARP & DOHME CORP. | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065671-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | GPR119, GPR39, GPR65 | KDM4E 3477/4885MEN1 3069/4885KMT2A 3444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.