Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.33 |
| ▸ | CECR2 | Q9BXF3 | 2/20 | 0.33 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | BRD1 | O95696 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrazinecarboxamide SCHEMBL1464482 | 0.84 | MAPT (0.33) | MAPTPPARGPPARAHDAC3HDAC1 | |
| SCHEMBL3348300 | 0.81 | PPARG (0.33) | MAPTPPARGPPARAHDAC3HDAC1 | |
| SCHEMBL1225834 | 0.80 | MAPT (0.34) | MAPTPOLBMEN1KMT2ATSHR | |
| SCHEMBL1226419 | 0.76 | ALDH1A1 (0.38) | MAPTPOLBMEN1KMT2ATSHR | |
| SCHEMBL2102964 | 0.74 | P2RX7 (0.52) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL6077004 | 0.68 | DUT (0.35) | MAPTTP53TSHRKDM4EGAA | |
| SCHEMBL6076773 | 0.68 | PTGER1 (0.42) | KDM4ECYP1A2 | |
| SCHEMBL31206670 | 0.66 | GLS (0.36) | MAPTPOLBTSHRKDM4EGAA | |
| SCHEMBL3342745 | 0.66 | KAT6A (0.42) | MAPTPPARGPPARAHDAC3HDAC1 | |
| SCHEMBL6077974 | 0.65 | KMT2A (0.38) | MAPTPOLBKMT2ATSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033055-A1 | FUSED TRIAZOLE AMINES AS P2X7 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-24 | — | — | WO | disclosed |