SCHEMBL1284980

SCHEMBL1284980

CCOCc1cc2ccc(OCc3ccccc3)cc2oc1=O

nearest known ligand 0.68

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAOB P27338 13/20 0.64
SLC16A3 O15427 1/20 0.62
MAOA P21397 5/20 0.60
MEN1 O00255 1/20 0.60
NPC1 O15118 1/20 0.60
CA12 O43570 1/20 0.60
CA1 P00915 1/20 0.60
CA2 P00918 1/20 0.60
CA3 P07451 1/20 0.60
CA4 P22748 1/20 0.60
CA6 P23280 1/20 0.60
CA7 P43166 1/20 0.60
MTNR1A P48039 1/20 0.60
KMT2A Q03164 1/20 0.60
CA9 Q16790 1/20 0.60
CA14 Q9ULX7 1/20 0.60
GPR55 Q9Y2T6 1/20 0.58
ACHE P22303 3/20 0.57
BCHE P06276 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29066609 0.84 SLC16A3 (0.70) MAOBSLC16A3MAOAMEN1NPC1
SCHEMBL1284982 0.82 GPR55 (0.62) MAOBSLC16A3MAOAMEN1NPC1
SCHEMBL1285503 0.82 MAOB (0.49) MAOBSLC16A3MAOAMEN1NPC1
SCHEMBL1285501 0.82 MAOB (0.49) MAOBSLC16A3MAOAMEN1NPC1
SCHEMBL1284769 0.79 MAOB (0.57) MAOBMAOAMEN1NPC1CA12
SCHEMBL4648135 0.79 SLC16A3 (0.66) MAOBSLC16A3MAOAMEN1NPC1
SCHEMBL22148003 0.78 MAOB (1.00) MAOBSLC16A3MAOACA12CA1
SCHEMBL93260 0.77 SLC16A3 (1.00) MAOBSLC16A3MAOAMEN1NPC1
SCHEMBL104995 0.76 AR (0.67) MAOBSLC16A3MAOAMEN1NPC1
SCHEMBL1093778 0.76 MAOB (0.72) MAOBSLC16A3MAOAMEN1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8383843-B2 Method for preparing a coumarin compound, chromene compound, and method for preparing a chromene compound KAOHSIUNG MEDICAL UNIVERSITY (TW) 2013-02-26 US disclosed
US-20120088923-A1 METHOD FOR PREPARING A COUMARIN COMPOUND, CHROMENE COMPOUND, AND METHOD FOR PREPARING A CHROMENE COMPOUND KAOHSIUNG MEDICAL UNIVERSITY (TW) 2012-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120088923-A1 METHOD FOR PREPARING A COUMARIN COMPOUND, CHROMENE COMPOUND, AND METHOD FOR PREPARING A CHROMENE COMPOUND CYP3A7, CYP2A7, F7 MAOB 327/4885SLC16A3 4578/4885MAOA 428/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.