SCHEMBL1284983

SCHEMBL1284983

COc1cc(/C=C\c2ccc(OC)c(N)c2)cc(OC)c1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO2 P16083 6/20 0.72
CYP1A1 P04798 4/20 0.72
CYP1B1 Q16678 4/20 0.72
TTR P02766 2/20 0.72
ABCG2 Q9UNQ0 1/20 0.72
MYC P01106 1/20 0.72
TUBB4A P04350 4/20 0.71
TUBB P07437 4/20 0.71
TUBA3C P0DPH7 4/20 0.71
TUBA1B P68363 4/20 0.71
TUBA4A P68366 4/20 0.71
TUBB4B P68371 4/20 0.71
TUBB3 Q13509 4/20 0.71
TUBB2A Q13885 4/20 0.71
TUBB8 Q3ZCM7 4/20 0.71
TUBA3E Q6PEY2 4/20 0.71
TUBA1A Q71U36 4/20 0.71
TUBA1C Q9BQE3 4/20 0.71
TUBB6 Q9BUF5 4/20 0.71
TUBB2B Q9BVA1 4/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1284984 1.00 NQO2 (0.72) NQO2CYP1A1CYP1B1TTRABCG2
SCHEMBL14027997 1.00 NQO2 (0.72) NQO2CYP1A1CYP1B1TTRABCG2
SCHEMBL2966692 0.91 ALOX5 (0.64) NQO2CYP1A1CYP1B1TTRABCG2
SCHEMBL2966686 0.91 ALOX5 (0.64) NQO2CYP1A1CYP1B1TTRABCG2
SCHEMBL2976605 0.90 NQO2 (0.59) NQO2CYP1A1CYP1B1TTRABCG2
SCHEMBL2971372 0.90 NQO2 (0.59) NQO2CYP1A1CYP1B1TTRABCG2
SCHEMBL2971377 0.90 NQO2 (0.59) NQO2CYP1A1CYP1B1TTRABCG2
SCHEMBL2976010 0.90 ESR1 (0.64) NQO2CYP1A1CYP1B1TTRABCG2
SCHEMBL2976014 0.90 ESR1 (0.64) NQO2CYP1A1CYP1B1TTRABCG2
SCHEMBL2976085 0.90 ESR1 (0.64) NQO2CYP1A1CYP1B1TTRABCG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116196427-A Compositions and methods for immune-mediated cancer therapy 泰克利森有限公司 2023-06-02 CN claimed
US-20190070186-A1 COMPOSITIONS AND METHODS FOR IMMUNE-MEDIATED CANCER THERAPY Teclison, Inc. 2019-03-07 US claimed
CN-108472366-A COMPOSITIONS AND METHODS FOR IMMUNE-MEDIATED CANCER THERAPY 泰克利森有限公司 2018-08-31 CN claimed
EP-3365015-A1 COMPOSITIONS AND METHODS FOR IMMUNE-MEDIATED CANCER THERAPY Teclison Limited (KY) 2018-08-29 EP claimed
US-9649316-B2 Induction of tumor hypoxia for cancer therapy VIRGINIA COMMONWEALTH UNIVERSITY (US) 2017-05-16 US claimed
WO-2017070606-A1 COMPOSITIONS AND METHODS FOR IMMUNE-MEDIATED CANCER THERAPY TECLISON LIMITED (KY) 2017-04-27 WO claimed
US-20140065139-A1 Induction of Tumor Hypoxia for Cancer Therapy VIRGINIA COMMONWEALTH UNIVERSITY (US) 2014-03-06 US claimed
WO-2009126705-A2 INDUCTION OF TUMOR HYPOXIA FOR CANCER THERAPY VIRGINIA COMMONWEALTH UNIVERSITY (US) 2009-10-15 WO claimed
US-20250255877-A1 COMPOSITIONS AND METHODS FOR IMMUNE-MEDIATED CANCER THERAPY Teclison, Inc. 2025-08-14 US disclosed
US-12350275-B2 Compositions and methods for immune-mediated cancer therapy Teclison, Inc. (US) 2025-07-08 US disclosed
CN-116196427-A Compositions and methods for immune-mediated cancer therapy 泰克利森有限公司 2023-06-02 CN disclosed
US-20230133566-A1 COMPOSITIONS AND METHODS FOR IMMUNE-MEDIATED CANCER THERAPY Teclison, Inc. 2023-05-04 US disclosed
US-11534445-B2 Compositions and methods for immune-mediated cancer therapy TECLISON LIMITED (KY) 2022-12-27 US disclosed
EP-3212613-B1 (Z)-3,4,5-TRIMETHOXYSTYRYLBENZENESULFONAMIDES AS POTENTIAL ANTICANCER AGENTS COUNCIL SCIENT IND RES (IN) 2020-12-16 EP disclosed
WO-2009126705-A2 INDUCTION OF TUMOR HYPOXIA FOR CANCER THERAPY VIRGINIA COMMONWEALTH UNIVERSITY (US) 2009-10-15 WO disclosed
WO-2008131320-A1 STILBENE DERIVATIVES AS NEW CANCER THERAPEUTIC AGENTS VIRGINIA COMMONWEALTH UNIVERSITY (US) 2008-10-30 WO disclosed
WO-2008131320-A1 STILBENE DERIVATIVES AS NEW CANCER THERAPEUTIC AGENTS VIRGINIA COMMONWEALTH UNIVERSITY (US) 2008-10-30 WO disclosed
US-20080261982-A1 STILBENE DERIVATIVES AS NEW CANCER THERAPEUTIC AGENTS VIRGINIA COMMONWEALTH UNIVERSITY 2008-10-23 US disclosed
US-20080261982-A1 STILBENE DERIVATIVES AS NEW CANCER THERAPEUTIC AGENTS VIRGINIA COMMONWEALTH UNIVERSITY 2008-10-23 US disclosed
US-20080261982-A1 STILBENE DERIVATIVES AS NEW CANCER THERAPEUTIC AGENTS VIRGINIA COMMONWEALTH UNIVERSITY 2008-10-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080261982-A1 STILBENE DERIVATIVES AS NEW CANCER THERAPEUTIC AGENTS HDGF, TIE1, VEGFA NQO2 4026/4885CYP1A1 2643/4885CYP1B1 1877/4885
US-20230133566-A1 COMPOSITIONS AND METHODS FOR IMMUNE-MEDIATED CANCER THERAPY CD47, HIF1AN, HIF1A NQO2 490/4885CYP1A1 2430/4885CYP1B1 3796/4885
US-11534445-B2 Compositions and methods for immune-mediated cancer therapy CD47, HIF1AN, HIF1A NQO2 490/4885CYP1A1 2430/4885CYP1B1 3796/4885
US-20140065139-A1 Induction of Tumor Hypoxia for Cancer Therapy HIF1A, HIF1AN, HYOU1 NQO2 990/4885CYP1A1 1941/4885CYP1B1 3885/4885
US-20190070186-A1 COMPOSITIONS AND METHODS FOR IMMUNE-MEDIATED CANCER THERAPY CD47, HIF1AN, HIF1A NQO2 490/4885CYP1A1 2430/4885CYP1B1 3796/4885
US-20250255877-A1 COMPOSITIONS AND METHODS FOR IMMUNE-MEDIATED CANCER THERAPY CD47, HIF1AN, HIF1A NQO2 490/4885CYP1A1 2430/4885CYP1B1 3796/4885
US-12350275-B2 Compositions and methods for immune-mediated cancer therapy CD47, HIF1AN, HIF1A NQO2 490/4885CYP1A1 2430/4885CYP1B1 3796/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.