SCHEMBL128524

SCHEMBL128524

[O]C(F)(F)C(F)(F)C(F)(F)C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.39
THRB P10828 1/20 0.38
CA2 P00918 3/20 0.35
CA1 P00915 2/20 0.33
MMP1 P03956 2/20 0.33
MMP2 P08253 2/20 0.33
MMP9 P14780 2/20 0.33
MMP8 P22894 2/20 0.33
MMP13 P45452 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1006646 0.96 LMNA (0.44) LMNATHRBCA2CA1MMP1
SCHEMBL910572 0.96 LMNA (0.44) LMNATHRBCA2CA1MMP1
SCHEMBL1005294 0.96 LMNA (0.44) LMNATHRBCA2CA1MMP1
SCHEMBL330805 0.96 LMNA (0.44) LMNATHRBCA2CA1MMP1
SCHEMBL1007075 0.96 LMNA (0.44) LMNATHRBCA2CA1MMP1
SCHEMBL1007393 0.96 LMNA (0.44) LMNATHRBCA2CA1MMP1
SCHEMBL1006397 0.96 LMNA (0.44) LMNATHRBCA2CA1MMP1
SCHEMBL843600 0.96 LMNA (0.44) LMNATHRBCA2CA1MMP1
SCHEMBL1006453 0.96 LMNA (0.44) LMNATHRBCA2CA1MMP1
SCHEMBL1005703 0.96 LMNA (0.44) LMNATHRBCA2CA1MMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3763 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2867019-B1 SLIDE BEARING COMPRISING A PRIMER SYSTEM AS ADHESION PROMOTER SAINT GOBAIN PERFORMANCE PLASTICS PAMPUS GMBH (DE) 2023-01-18 EP claimed
CN-112018441-B Lithium secondary battery electrolyte, preparation method thereof and lithium secondary battery 华为技术有限公司 2022-04-12 CN claimed
CN-107586370-B Block polymer and random polymer for directed self-assembly, and preparation method and self-assembly method thereof 北京科华微电子材料有限公司 2021-03-09 CN claimed
CN-112018441-A Lithium secondary battery electrolyte, preparation method thereof and lithium secondary battery 华为技术有限公司 2020-12-01 CN claimed
EP-2086924-B1 [F-18]-LABELED L-GLUTAMIC ACID, [F-18]-LABELED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF AND PROCESSES FOR THEIR PREPARATION PIRAMAL IMAGING SA (CH) 2018-09-12 EP claimed
US-9375497-B2 [F-18]-labeled L-glutamic acid, [F-18]-labeled L-glutamine, derivatives thereof and use thereof and processes for their preparation PIRAMAL IMAGING SA (CH) 2016-06-28 US claimed
US-20140301948-A1 [F-18]-LABELED L-GLUTAMIC ACID, [F-18]-LABELED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF AND PROCESSES FOR THEIR PREPARATION BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2014-10-09 US claimed
US-20100217011-A1 [F-18]-LABELED L-GLUTAMIC ACID, [F-18]-LABELED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF AND PROCESSES FOR THEIR PREPARATION BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2010-08-26 US claimed
EP-2123619-A1 New [F-18]-marked L-glutamic acids and L-glutamic acid derivatives (II), application thereof and method for their manufacture Bayer Schering Pharma AG (DE) 2009-11-25 EP claimed
EP-2123621-A1 New [F-18]-marked L-glutamic acids and L-glutamic acid derivatives (1), application thereof and method for their manufacture Bayer Schering Pharma Aktiengesellschaft (DE) 2009-11-25 EP claimed
EP-1923382-A1 [18F] labelled L-glutamic acid, [18F] labelled glutamine, their derivatives, their use and processes for their preparation Bayer Schering Pharma Aktiengesellschaft (DE) 2008-05-21 EP claimed
WO-2008052788-A1 [F-18]-LABELED L-GLUTAMIC ACID, [F-18]-LABELED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF AND PROCESSES FOR THEIR PREPARATION BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-05-08 WO claimed
US-6713468-B2 AS ANTICONVULSANTS; FOR THERAPY AND PROPHYLAXIS OF ISCHAEMIAS, ANOXIA, NEURODEGENERATIVE DISEASES AVENTIS PHARMA S.A. (FR) 2004-03-30 US claimed
US-20030055031-A1 Methods of using thiazolobenzoheterocycles RHONE-POULENC RORER S.A. 2003-03-20 US claimed
US-6448241-B1 THESE COMPOUNDS ARE ANTICONVULSANTS AND INTERFERE WITH GLUTAMATERGIC TRANSMISSION AND ARE THEREFORE USEFUL FOR THE TREATMENT OR PREVENTION OF ALL ISCHAEMIAS FOLLOWING CEREBROVASCULAR ACCIDENTS AVENTIS PHARMA S.A. (FR) 2002-09-10 US claimed
EP-0966473-B1 THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME AVENTIS PHARMA SA (FR) 2002-07-24 EP claimed
US-6423715-B1 ANTICONVULSANTS AVENTIS PHARMA S.A. (FR) 2002-07-23 US claimed
US-6288075-B1 ANTIEPILEPTIC AGENTS; NERVOUS SYSTEM, BRAIN, AND CARDIOVASCULAR DISORDERS RHONE-POULENC RORER S.A. (FR) 2001-09-11 US claimed
EP-0966473-A1 THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME Aventis Pharma S.A. (FR) 1999-12-29 EP claimed
WO-1998038194-A1 THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME RHONE-POULENC RORER S.A. (FR) 1998-09-03 WO claimed