Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 12/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 12/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.52 |
| ▸ | HTR5A | P47898 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TERT | O14746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19323877 | 0.80 | POLB (0.45) | ALDH1A1LMNA | |
| SCHEMBL19151081 | 0.80 | CYP2C9 (0.52) | LMNA | |
| SCHEMBL19323874 | 0.79 | LMNA (0.46) | ALDH1A1LMNA | |
| SCHEMBL5263496 | 0.78 | ADORA2A (0.54) | HDAC6ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL28431375 | 0.78 | ALDH1A1 (0.48) | HDAC6ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL643810 | 0.77 | KDM4E (0.54) | HDAC6HTR5AALDH1A1LMNA | |
| SCHEMBL19151066 | 0.77 | CARM1 (0.49) | LMNA | |
| SCHEMBL31036966 | 0.77 | LMNA (0.56) | LMNA | |
| SCHEMBL19631316 | 0.76 | HDAC6 (0.77) | HDAC6ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL29647751 | 0.76 | HDAC6 (0.77) | HDAC6ADORA2AADORA1ADORA3ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180305373-A1 | ALPHA HELIX MIMETICS AND METHODS RELATING THERETO | Prism BioLab Co., Ltd. (JP) | 2018-10-25 | — | — | US | disclosed |
| US-10017522-B2 | Alpha helix mimetics and methods relating thereto | Prism BioLab Co., Ltd. (JP) | 2018-07-10 | — | — | US | disclosed |
| US-20150368262-A1 | ALPHA HELIX MIMETICS AND METHODS RELATING THERETO | Prism BioLab Co., Ltd. (JP) | 2015-12-24 | — | — | US | disclosed |
| US-9040531-B2 | Alpha helix mimetics and methods relating thereto | Prism BioLab Co., Ltd. (JP) | 2015-05-26 | — | — | US | disclosed |
| US-20120088770-A1 | ALPHA HELIX MIMETICS AND METHODS RELATING THERETO | PRISM BIOLAB CORPORATION (JP) | 2012-04-12 | — | — | US | disclosed |
| CN-102046628-A | Alpha helix mimetics and methods relating thereto | PRISM BIOLAB CORP | 2011-05-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150368262-A1 | ALPHA HELIX MIMETICS AND METHODS RELATING THERETO | PLOD3, COL1A1, THPO | HDAC6 1696/4885ADORA2A 3937/4885ADORA1 2545/4885 |
| US-20120088770-A1 | ALPHA HELIX MIMETICS AND METHODS RELATING THERETO | PLOD3, COL1A1, THPO | HDAC6 1696/4885ADORA2A 3937/4885ADORA1 2545/4885 |
| US-20180305373-A1 | ALPHA HELIX MIMETICS AND METHODS RELATING THERETO | PLOD3, COL1A1, THPO | HDAC6 1696/4885ADORA2A 3937/4885ADORA1 2545/4885 |
| US-10017522-B2 | Alpha helix mimetics and methods relating thereto | PLOD3, COL1A1, THPO | HDAC6 1696/4885ADORA2A 3937/4885ADORA1 2545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.