Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12863834 | 0.91 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1SMN1; SMN2CYP1A2MAPK1 | |
| SCHEMBL12863854 | 0.88 | PAOX (0.45) | ALDH1A1L3MBTL1SMN1; SMN2HRH3HRH1 | |
| SCHEMBL12844635 | 0.82 | CYP19A1 (0.41) | ALDH1A1L3MBTL1SMN1; SMN2HRH1HRH2 | |
| SCHEMBL23453791 | 0.82 | SMN1; SMN2 (0.45) | ALDH1A1L3MBTL1SMN1; SMN2CYP1A2MAPK1 | |
| SCHEMBL12863836 | 0.81 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1SMN1; SMN2MAPK1KMT2A | |
| SCHEMBL15027779 | 0.80 | ALDH1A1 (0.45) | ALDH1A1L3MBTL1SMN1; SMN2CYP1A2MAPK1 | |
| SCHEMBL10081284 | 0.80 | SMN1; SMN2 (0.44) | ALDH1A1L3MBTL1SMN1; SMN2CYP1A2MAPK1 | |
| SCHEMBL23453781 | 0.79 | SMN1; SMN2 (0.42) | ALDH1A1L3MBTL1SMN1; SMN2CYP1A2MAPK1 | |
| SCHEMBL1863035 | 0.79 | CYP1A2 (0.56) | ALDH1A1L3MBTL1SMN1; SMN2CYP1A2MAPK1 | |
| SCHEMBL856060 | 0.79 | CYP1A2 (0.56) | ALDH1A1L3MBTL1SMN1; SMN2CYP1A2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110034434-A1 | PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2011-02-10 | — | — | US | disclosed |
| US-20100120740-A1 | PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120740-A1 | PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | DDO, DAO, AOC1 | ALDH1A1 350/4885L3MBTL1 2568/4885SMN1; SMN2 1880/4885 |
| US-20110034434-A1 | PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | DDO, DAO, AOC1 | ALDH1A1 350/4885L3MBTL1 2568/4885SMN1; SMN2 1880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.