Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 5/20 | 0.48 |
| ▸ | GNAO1 | P09471 | 5/20 | 0.48 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.48 |
| ▸ | DRD2 | P14416 | 5/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL471116 | 1.00 | GNAI3 (0.48) | GNAI3GNAO1GNAI1DRD2SLC6A4 | |
| SCHEMBL24688126 | 0.89 | SIGMAR1 (0.43) | GNAI3GNAO1GNAI1DRD2SMN1; SMN2 | |
| SCHEMBL19501243 | 0.87 | GNAI3 (0.55) | GNAI3GNAO1GNAI1DRD2SLC6A4 | |
| SCHEMBL23643862 | 0.83 | GNAI3 (0.52) | GNAI3GNAO1GNAI1DRD2PABPC1 | |
| SCHEMBL12513465 | 0.83 | GNAI3 (0.52) | GNAI3GNAO1GNAI1DRD2PABPC1 | |
| SCHEMBL7738925 | 0.81 | GNAI3 (0.50) | GNAI3GNAO1GNAI1DRD2PABPC1 | |
| SCHEMBL8324635 | 0.80 | DRD2 (0.47) | GNAI3GNAO1GNAI1DRD2SLC6A4 | |
| SCHEMBL23875383 | 0.79 | GNAI3 (0.53) | GNAI3GNAO1GNAI1DRD2PABPC1 | |
| SCHEMBL19416662 | 0.79 | SMN1; SMN2 (0.46) | GNAI3GNAO1GNAI1SMN1; SMN2 | |
| SCHEMBL27340689 | 0.78 | GNAO1 (0.71) | GNAI3GNAO1GNAI1DRD2PABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651612-B9 | 3,4-DISUBSTITUTED 1H-PYRAZOLE COMPOUNDS AND THEIR USE AS CYCLIN DEPENDENT KINASES (CDK) AND GLYCOGEN SYNTHASE KINASE-3 (GSK-3) MODULATORS | ASTEX THERAPEUTICS LTD (GB) | 2012-09-05 | — | — | EP | disclosed |
| EP-1651612-B1 | 3,4-DISUBSTITUTED 1H-PYRAZOLE COMPOUNDS AND THEIR USE AS CYCLIN DEPENDENT KINASES (CDK) AND GLYCOGEN SYNTHASE KINASE-3 (GSK-3) MODULATORS | ASTEX THERAPEUTICS LTD (GB) | 2012-04-11 | — | — | EP | disclosed |