Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.71 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.71 |
| ▸ | ESR1 | P03372 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10711420 | 0.83 | ESR1 (0.54) | GABRA1GABRB2ESR1ALOX15KDM4E | |
| SCHEMBL318750 | 0.83 | GABRA1 (1.00) | GABRA1GABRB2ESR1ALOX15KDM4E | |
| SCHEMBL7922257 | 0.82 | GABRA1 (0.81) | GABRA1GABRB2ESR1ALOX15KDM4E | |
| SCHEMBL5164953 | 0.81 | GABRA1 (0.73) | GABRA1GABRB2ESR1ALOX15KDM4E | |
| SCHEMBL6341702 | 0.81 | ALOX15 (0.67) | GABRA1GABRB2ESR1ALOX15KDM4E | |
| SCHEMBL6341699 | 0.81 | ALOX15 (0.67) | GABRA1GABRB2ESR1ALOX15KDM4E | |
| SCHEMBL5167205 | 0.80 | GABRA1 (0.79) | GABRA1GABRB2ESR1ALOX15KDM4E | |
| SCHEMBL4460242 | 0.79 | ALOX5 (0.54) | GABRA1GABRB2ESR1ALOX15KDM4E | |
| SCHEMBL28916258 | 0.79 | GABRA1 (0.89) | GABRA1GABRB2ESR1ALOX15KDM4E | |
| SCHEMBL21785848 | 0.78 | GABRA1 (0.55) | GABRA1GABRB2ESR1ALOX15KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110046160-A1 | Novel Class of Spiro Piperidines for the Treatment of Neurodegenerative Diseases | PFIZER, INC. | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046160-A1 | Novel Class of Spiro Piperidines for the Treatment of Neurodegenerative Diseases | SNCA, PARK7, HTT | GABRA1 1390/4885GABRB2 1478/4885ESR1 3479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.