Sugi Predict

Sugi Predict / Compounds / SCHEMBL1286855

SCHEMBL1286855

SCHEMBL1286855

CCCCCC(C=C(C)C(=O)O)(CCCCC)CCCCC

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EP300 Q09472 1/20 0.38
▸ CES2 O00748 1/20 0.37
▸ THRB P10828 1/20 0.37
▸ FNTA P49354 1/20 0.37
▸ FNTB P49356 1/20 0.37
▸ PGGT1B P53609 1/20 0.37
▸ AKR1B1 P15121 1/20 0.37
▸ GPR84 Q9NQS5 7/20 0.35
▸ PPARG P37231 6/20 0.35
▸ PPARD Q03181 6/20 0.35
▸ PPARA Q07869 6/20 0.35
▸ HDAC11 Q96DB2 5/20 0.35
▸ TSHR P16473 4/20 0.35
▸ ALDH1A1 P00352 2/20 0.35
▸ TLR2 O60603 2/20 0.35
▸ TDP1 Q9NUW8 2/20 0.35
▸ FABP4 P15090 2/20 0.35
▸ PTPN1 P18031 2/20 0.35
▸ SLC22A6 Q4U2R8 1/20 0.35
▸ SLC22A8 Q8TCC7 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1286854 1.00 EP300 (0.38) EP300CES2THRBFNTAFNTB
SCHEMBL15055306 0.85 PTGS1 (0.30) —
SCHEMBL15055305 0.85 PTGS1 (0.30) —
SCHEMBL5856231 0.82 EP300 (0.37) EP300CES2THRBFNTAFNTB
SCHEMBL15791978 0.81 EP300 (0.40) EP300CES2THRBFNTAFNTB
SCHEMBL15577114 0.81 CES2 (0.43) EP300CES2THRBFNTAFNTB
SCHEMBL15791892 0.81 EP300 (0.40) EP300CES2THRBFNTAFNTB
SCHEMBL8366244 0.81 FDPS (0.36) EP300CES2THRBFNTAFNTB
SCHEMBL9418790 0.79 CES2 (0.46) EP300CES2THRBFNTAFNTB
SCHEMBL561739 0.79 CES2 (0.46) EP300CES2THRBFNTAFNTB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240240161-A1 DP04 POLYMERASE VARIANTS Roche Sequencing Solutions, Inc. 2024-07-18 — — US disclosed
EP-3619321-B1 DP04 POLYMERASE VARIANTS ROCHE DIAGNOSTICS GMBH (DE) 2024-07-17 — — EP disclosed
US-12037577-B2 DPO4 polymerase variants Roche Sequencing Solutions, Inc. (US) 2024-07-16 — — US disclosed
US-11970731-B2 Enhancement of nucleic acid polymerization by aromatic compounds Roche Sequencing Solutions, Inc. (US) 2024-04-30 — — US disclosed
US-20230313157-A1 DP04 POLYMERASE VARIANTS WITH IMPROVED ACCURACY Roche Sequencing Solutions, Inc. 2023-10-05 — — US disclosed
US-11708566-B2 DP04 polymerase variants STRATOS GENOMICS, INC. (US) 2023-07-25 — — US disclosed
EP-3735409-B1 ENHANCEMENT OF NUCLEIC ACID POLYMERIZATION BY AROMATIC COMPOUNDS STRATOS GENOMICS INC (US) 2023-06-21 — — EP disclosed
US-11530392-B2 DPO4 polymerase variants with improved accuracy STRATOS GENOMICS, INC. (US) 2022-12-20 — — US disclosed
US-20220186205-A1 DPO4 POLYMERASE VARIANTS Roche Sequencing Solutions, Inc. 2022-06-16 — — US disclosed
EP-3994262-A1 ENHANCEMENT OF NUCLEIC ACID POLYMERIZATION BY AROMATIC COMPOUNDS Stratos Genomics Inc. (US) 2022-05-11 — — EP disclosed
US-8592182-B2 High throughput nucleic acid sequencing by spacing STRATOS GENOMICS INC. (US) 2013-11-26 — — US disclosed
US-20130165350-A1 SURFACE LINKERS FOR ARRAY SYNTHESIS AFFYMETRIX, INC. (US) 2013-06-27 — — US disclosed
US-8349565-B2 High throughput nucleic acid sequencing by expansion STRATOS GENOMICS, INC. (US) 2013-01-08 — — US disclosed
US-8324360-B2 High throughput nucleic acid sequencing by expansion STRATOS GENOMICS, INC. (US) 2012-12-04 — — US disclosed
US-20120088235-A1 HIGH THROUGHPUT NUCLEIC ACID SEQUENCING BY EXPANSION AND RELATED METHODS STRATOS GENOMICS, INC. (US) 2012-04-12 — — US disclosed
US-20110251079-A1 HIGH THROUGHPUT NUCLEIC ACID SEQUENCING BY EXPANSION STRATOS GENOMICS, INC. (US) 2011-10-13 — — US disclosed
US-20110237787-A1 HIGH THROUGHPUT NUCLEIC ACID SEQUENCING BY EXPANSION STRATOS GENOMICS, INC. (US) 2011-09-29 — — US disclosed
US-7939259-B2 High throughput nucleic acid sequencing by expansion STRATOS GENOMICS, INC. (US) 2011-05-10 — — US disclosed
US-20100297644-A1 HIGH THROUGHPUT NUCLEIC ACID SEQUENCING BY SPACING STRATOS GENOMICS INC. (US) 2010-11-25 — — US disclosed
US-20090035777-A1 HIGH THROUGHPUT NUCLEIC ACID SEQUENCING BY EXPANSION Roche Sequencing Solutions, Inc. 2009-02-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120088235-A1 HIGH THROUGHPUT NUCLEIC ACID SEQUENCING BY EXPANSION AND RELATED METHODS POLRMT, POLM, NSUN2 EP300 4777/4885CES2 2755/4885THRB 4045/4885
US-20220186205-A1 DPO4 POLYMERASE VARIANTS POLM, POLN, POLB EP300 1429/4885CES2 4631/4885THRB 4148/4885
US-20090035777-A1 HIGH THROUGHPUT NUCLEIC ACID SEQUENCING BY EXPANSION ERCC4, NUDT21, CPSF6 EP300 4524/4885CES2 2120/4885THRB 4149/4885
US-12037577-B2 DPO4 polymerase variants POLM, POLN, POLB EP300 1429/4885CES2 4631/4885THRB 4148/4885
US-20110237787-A1 HIGH THROUGHPUT NUCLEIC ACID SEQUENCING BY EXPANSION ERCC4, NUDT21, CPSF6 EP300 4524/4885CES2 2120/4885THRB 4149/4885
US-11970731-B2 Enhancement of nucleic acid polymerization by aromatic compounds POLN, POLB, POLRMT EP300 1431/4885CES2 1291/4885THRB 4549/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.