Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | TOP1 | P11387 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TTR | P02766 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27558184 | 0.90 | PTPRC (0.55) | PIM1TOP1MAPK1KDM4EALDH1A1 | |
| SCHEMBL1287104 | 0.83 | TOP1 (0.65) | PIM1TOP1MAPK1KDM4EALDH1A1 | |
| SCHEMBL27407860 | 0.82 | POLM (0.52) | TOP1MAPK1KDM4EALDH1A1HPGD | |
| SCHEMBL27370235 | 0.80 | POLM (0.60) | TOP1KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL27366686 | 0.79 | TYMS (0.47) | TOP1MAPK1KDM4EALDH1A1HPGD | |
| SCHEMBL27461372 | 0.79 | POLM (0.46) | TOP1MAPK1KDM4EALDH1A1HPGD | |
| SCHEMBL29018326 | 0.78 | TOP1 (0.67) | PIM1TOP1KDM4EALDH1A1HPGD | |
| SCHEMBL14566959 | 0.74 | ADORA2A (0.49) | PIM1MAPK1KDM4EALDH1A1ADORA3 | |
| SCHEMBL8676653 | 0.73 | PTGS2 (0.61) | MAPK1KDM4EALDH1A1HPGDLMNA | |
| SCHEMBL5613348 | 0.71 | ALDH1A1 (0.73) | PIM1MAPK1KDM4EALDH1A1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1063180-C | 5H, 10H-imidazo [1, 2 -a] indeno [1, 2 -e] pyrazin-4-one derivatives, preparation thereof, and drugs containing said derivatives | RHONE POULENC RORER SA (FR) | 2001-03-14 | — | — | CN | disclosed |
| CN-1180357-A | 5H, 10H-imidazo [1, 2-a ] indeno [1, 2-e ] pyrazin-4-one derivatives, preparation thereof and medicaments containing same | RHONE POULENC RORER SA (FR) | 1998-04-29 | — | — | CN | disclosed |