Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GMNN | O75496 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13563783 | 0.82 | BRD4 (0.38) | BRD4ADORA3ADORA2AADORA1ALDH1A1 | |
| SCHEMBL22898718 | 0.78 | ALDH1A1 (0.38) | BRD4ADORA3ADORA2AADORA1ALDH1A1 | |
| SCHEMBL23050973 | 0.78 | BRD4 (0.41) | BRD4ADORA3ADORA2AADORA1ALDH1A1 | |
| SCHEMBL22404895 | 0.77 | BRD4 (0.38) | BRD4ALDH1A1GAAKDM4ECYP3A4 | |
| SCHEMBL23055166 | 0.75 | BRD4 (0.36) | BRD4ADORA3ADORA2AADORA1ALDH1A1 | |
| SCHEMBL10328259 | 0.75 | HPSE (0.41) | BRD4ALDH1A1GAASMN1; SMN2KDM4E | |
| SCHEMBL12872113 | 0.74 | BRD4 (0.36) | BRD4ALDH1A1GAAFAAHMGLL | |
| SCHEMBL10328047 | 0.73 | SLC9A1 (0.44) | ADORA3ADORA2AADORA1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3605357 | 0.72 | PARP1 (0.39) | BRD4ADORA3ADORA2AADORA1ALDH1A1 | |
| SCHEMBL4204720 | 0.71 | BRD4 (0.34) | BRD4ALDH1A1GAASMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8471006-B2 | Coupling agents for peptide synthesis | UNIVERSITY OF MASSACHUSETTS (US) | 2013-06-25 | — | — | US | disclosed |
| US-20120277428-A1 | NEW COUPLING AGENTS FOR PEPTIDE SYNTHESIS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-11-01 | — | — | US | disclosed |
| US-20110028720-A1 | New Coupling Agents for Peptide Synthesis | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120277428-A1 | NEW COUPLING AGENTS FOR PEPTIDE SYNTHESIS | NGLY1, NPPA, VIP | BRD4 3205/4885ADORA3 4630/4885ADORA2A 4840/4885 |
| US-20110028720-A1 | New Coupling Agents for Peptide Synthesis | NGLY1, NPPA, VIP | BRD4 3205/4885ADORA3 4630/4885ADORA2A 4840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.